Anti-WDR12 Antibody (CAB15477)
- SKU:
- CAB15477
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-WDR12 Antibody |
| 抗体コード: | CAB15477 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human WDR12 (NP_060726.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A431, HeLa, Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human WDR12 (NP_060726.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAQL QTRF YTDN KKYA VDDV PFSI PAAS EIAD LSNI INKL LKDK NEFH KHVE FDFL IKGQ FLRM PLDK HMEM ENIS SEEV VEIE YVEK YTAP QPEQ CMFH DDWI SSIK GAEE WILT GSYD KTSR IWSL EGKS IMTI VGHT DVVK DVAW VKKD SLSC LLLS ASMD QTIL LWEW NVER NKVK ALHC CRGH AGSV DSIA VDGS GTKF CSGS WDKM LKIW STVP TDEE DEME ESTN RPRK KQKT EQLG LTRT PIVT LSGH MEAV SSVL WSDA EEIC SASW DHTI |
| 遺伝子ID: | 55759 |
| Uniprot: | Q9GZL7 |
| セルラーロケーション: | Nucleus, nucleolus, nucleoplasm |
| 計算された分子量: | 47kDa |
| 観察された分子量: | 50kDa |
| 同義語: | WDR12, YTM1 |
| バックグラウンド: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit. |
| UniProt Protein Function: | WDR12: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the WD repeat WDR12/YTM1 family. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 2q33.2 Cellular Component: nucleolus; nucleoplasm Molecular Function:protein binding Biological Process: cell proliferation; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis and assembly; rRNA processing |
| NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein is highly similar to the mouse WD repeat domain 12 protein at the amino acid level. The protein encoded by this gene is a component of a nucleolar protein complex that affects maturation of the large ribosomal subunit.[provided by RefSeq, Dec 2008] |
| UniProt Code: | Q9GZL7 |
| NCBI GenInfo Identifier: | 20140802 |
| NCBI Gene ID: | 55759 |
| NCBI Accession: | Q9GZL7.2 |
| UniProt Secondary Accession: | Q9GZL7,Q96HU0, Q9NV80, Q9NYI8, B3KPA9, |
| UniProt Related Accession: | Q9GZL7 |
| Molecular Weight: | 47,708 Da |
| NCBI Full Name: | Ribosome biogenesis protein WDR12 |
| NCBI Synonym Full Names: | WD repeat domain 12 |
| NCBI Official Symbol: | WDR12 |
| NCBI Official Synonym Symbols: | YTM1 |
| NCBI Protein Information: | ribosome biogenesis protein WDR12 |
| UniProt Protein Name: | Ribosome biogenesis protein WDR12 |
| UniProt Synonym Protein Names: | WD repeat-containing protein 12 |
| Protein Family: | Ribosome biogenesis protein |
| UniProt Gene Name: | WDR12 |
| UniProt Entry Name: | WDR12_HUMAN |
 | Western blot analysis of extracts of various cell lines, using WDR12 antibody (CAB15477) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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