Anti-VTI1A Antibody (CAB5162)
- SKU:
- CAB5162
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-VTI1A Antibody |
| 抗体コード: | CAB5162 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human VTI1A (NP_660207.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, HT-1080, Mouse lung, Mouse kidney, Mouse brain, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human VTI1A (NP_660207.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSSD FEGY EQDF AVLT AEIT SKIA RVPR LPPD EKKQ MVAN VEKQ LEEA KELL EQMD LEVR EIPP QSRG MYSN RMRS YKQE MGKL ETDF KRSR IAYS DEVR NELL GDDG NSSE NQRA HLLD NTER LERS SRRL EAGY QIAV ETEQ IGQE MLEN LSHD REKI QRAR ERLR ETDA NLGK SSRI |
| 遺伝子ID: | 143187 |
| Uniprot: | Q96AJ9 |
| セルラーロケーション: | Cytoplasmic vesicle, Golgi apparatus membrane, Single-pass type IV membrane protein |
| 計算された分子量: | 23kDa/25kDa |
| 観察された分子量: | 30kDa |
| 同義語: | VTI1A, MMDS3, MVti1, VTI1RP2, Vti1-rp2 |
| バックグラウンド: | The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | VTI1A: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 10q25.2 Cellular Component: autophagic vacuole; cell soma; clathrin-coated vesicle; endosome; Golgi apparatus; Golgi membrane; integral to membrane; perinuclear region of cytoplasm; SNARE complex; synaptic vesicle Molecular Function:protein binding; SNAP receptor activity; SNARE binding Biological Process: autophagy; ER to Golgi vesicle-mediated transport; intracellular protein transport; retrograde transport, endosome to Golgi; vesicle fusion with Golgi apparatus; voluntary musculoskeletal movement Disease: Multiple Mitochondrial Dysfunctions Syndrome 3 |
| NCBI Summary: | The protein encoded by this gene is a member of the family of soluble N-ethylmaleimide-sensitive fusion protein-attachment protein receptors (SNAREs) that function in intracellular trafficking. This family member is involved in vesicular transport between endosomes and the trans-Golgi network. It is a vesicle-associated SNARE (v-SNARE) that interacts with target membrane SNAREs (t-SNAREs). Polymorphisms in this gene have been associated with binocular function, and also with susceptibility to colorectal and lung cancers. A recurrent rearrangement has been found between this gene and the transcription factor 7-like 2 (TCF7L2) gene in colorectal cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q96AJ9 |
| NCBI GenInfo Identifier: | 374095459 |
| NCBI Gene ID: | 143187 |
| NCBI Accession: | Q96AJ9.2 |
| UniProt Secondary Accession: | Q96AJ9,Q5W0D7, A2A307, B4E137, |
| UniProt Related Accession: | Q96AJ9 |
| Molecular Weight: | 23,435 Da |
| NCBI Full Name: | Vesicle transport through interaction with t-SNAREs homolog 1A |
| NCBI Synonym Full Names: | vesicle transport through interaction with t-SNAREs 1A |
| NCBI Official Symbol: | VTI1A |
| NCBI Official Synonym Symbols: | MMDS3; MVti1; VTI1RP2; Vti1-rp2 |
| NCBI Protein Information: | vesicle transport through interaction with t-SNAREs homolog 1A |
| UniProt Protein Name: | Vesicle transport through interaction with t-SNAREs homolog 1A |
| UniProt Synonym Protein Names: | Vesicle transport v-SNARE protein Vti1-like 2; Vti1-rp2 |
| Protein Family: | Vesicle transport through interaction with t-SNAREs |
| UniProt Gene Name: | VTI1A |
| UniProt Entry Name: | VTI1A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using VTI1A antibody (CAB5162) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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