| UniProt Protein Function: | Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714). |
| NCBI Summary: | The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y4B6 |
| NCBI GenInfo Identifier: | 13111964 |
| NCBI Gene ID: | 11316 |
| NCBI Accession: | BC003155 |
| UniProt Secondary Accession: | Q9Y4B6,O76097, Q6IBB8, Q9UGP6, A6NE29, A6NKA3, |
| UniProt Related Accession: | O14579 |
| Molecular Weight: | 28,773 Da |
| NCBI Full Name: | Homo sapiens coatomer protein complex, subunit epsilon, mRNA |
| NCBI Synonym Full Names: | coatomer protein complex subunit epsilon |
| NCBI Official Symbol: | COPE |
| NCBI Official Synonym Symbols: | epsilon-COP |
| NCBI Protein Information: | coatomer subunit epsilon |
| UniProt Protein Name: | DDB1- and CUL4-associated factor 1 |
| UniProt Synonym Protein Names: | HIV-1 Vpr-binding protein; VprBP; Serine/threonine-protein kinase VPRBP (EC:2.7.11.1); Vpr-interacting protein |
| Protein Family: | Coatomer |
| UniProt Gene Name: | DCAF1 |
