Anti-USP46 Antibody (CAB17863)
- SKU:
- CAB17863
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
抗体名: | Anti-USP46 Antibody |
抗体コード: | CAB17863 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic Peptide of human USP46 |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | mouse pancreas |
免疫原: | A synthetic Peptide of human USP46 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 64854 |
Uniprot: | P62068 |
セルラーロケーション: | |
計算された分子量: | 26kDa/41kDa/42kDa |
観察された分子量: | 42kDa |
同義語: | USP46 |
バックグラウンド: |
UniProt Protein Function: | USP46: Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. Belongs to the peptidase C19 family. USP12/USP46 subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; EC 3.4.19.12; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 4q12 Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: ubiquitin-dependent protein catabolic process; protein deubiquitination; behavioral fear response; righting reflex; adult feeding behavior; behavioral response to ethanol; regulation of synaptic transmission, GABAergic |
NCBI Summary: | Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009] |
UniProt Code: | P62068 |
NCBI GenInfo Identifier: | 49065850 |
NCBI Gene ID: | 64854 |
NCBI Accession: | P62068.1 |
UniProt Secondary Accession: | P62068,Q80V95, Q9H7U4, Q9H9T8, B7Z3Y7, B7Z675, B7Z7S3 G8ACC7, |
UniProt Related Accession: | P62068 |
Molecular Weight: | 366 |
NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 46 |
NCBI Official Symbol: | USP46 |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 46; ubiquitin thioesterase 46; deubiquitinating enzyme 46; ubiquitin thiolesterase 46; ubiquitin-specific-processing protease 46 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 46 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme 46; Ubiquitin thioesterase 46; Ubiquitin-specific-processing protease 46 |
Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
UniProt Gene Name: | USP46 |
UniProt Entry Name: | UBP46_HUMAN |
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