| UniProt Protein Function: | UGT2B4: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4- nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid. Belongs to the UDP-glycosyltransferase family. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - pentose and glucuronate interconversions; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - ascorbate and aldarate; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen Chromosomal Location of Human Ortholog: 4q13.3 Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; integral to membrane Molecular Function:retinoic acid binding; glucuronosyltransferase activity Biological Process: flavonoid biosynthetic process; metabolic process; xenobiotic metabolic process; estrogen catabolic process; cellular response to hormone stimulus |
| UniProt Code: | P06133 |
| NCBI GenInfo Identifier: | 6175083 |
| NCBI Gene ID: | 7363 |
| NCBI Accession: | P06133.2 |
| UniProt Secondary Accession: | P06133,O60731, O60867, O75614, P36538, Q1HBF9, Q6QQX7 A6NCP7, B4DT75, G5E9X8, |
| UniProt Related Accession: | P06133 |
| Molecular Weight: | Observed MW: 50kDaCalculated MW: 42kDa/44kDa/60kDa |
| NCBI Full Name: | UDP-glucuronosyltransferase 2B4 |
| NCBI Synonym Full Names: | UDP glucuronosyltransferase 2 family, polypeptide B4 |
| NCBI Official Symbol: | UGT2B4 |
| NCBI Official Synonym Symbols: | HLUG25; UDPGTH1; UGT2B11; UDPGT2B4; UDPGTh-1 |
| NCBI Protein Information: | UDP-glucuronosyltransferase 2B4; UDPGT 2B4; hyodeoxycholic acid; hyodeoxycholic acid-specific UDPGT; UDP-glucuronyltransferase, family 2, beta-4 |
| UniProt Protein Name: | UDP-glucuronosyltransferase 2B4 |
| UniProt Synonym Protein Names: | HLUG25; Hyodeoxycholic acid-specific UDPGT; UDPGTh-1 |
| Protein Family: | UDP-glucuronosyltransferase |
| UniProt Gene Name: | UGT2B4 |
| UniProt Entry Name: | UD2B4_HUMAN |
