Anti-UCN2 Antibody (CAB6485)
- SKU:
- CAB6485
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-UCN2 Antibody |
| 抗体コード: | CAB6485 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-112 of human UCN2 (NP_149976.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Rat skin |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-112 of human UCN2 (NP_149976.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VPVT PIPT FQLR PQNS PQTT PRPA ASES PSAA PTWP WAAQ SHCS PTRH PGSR IVLS LDVP IGLL QILL EQAR ARAA REQA TTNA RILA RVGH C |
| 遺伝子ID: | 90226 |
| Uniprot: | Q96RP3 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 12kDa |
| 観察された分子量: | 12kDa |
| 同義語: | UCN2, SRP, UCN-II, UCNI, UR, URP |
| バックグラウンド: | This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. |
| UniProt Protein Function: | UCN2: Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: extracellular space; extracellular region Molecular Function:hormone binding; G-protein-coupled receptor binding; hormone activity; corticotropin-releasing hormone receptor 2 binding; receptor binding Biological Process: cell proliferation; negative regulation of luteinizing hormone secretion; cellular response to nutrient levels; digestion; response to stress; cAMP biosynthetic process; G-protein signaling, adenylate cyclase activating pathway; negative regulation of follicle-stimulating hormone secretion |
| NCBI Summary: | This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96RP3 |
| NCBI GenInfo Identifier: | 20532289 |
| NCBI Gene ID: | 90226 |
| NCBI Accession: | Q96RP3.1 |
| UniProt Secondary Accession: | Q96RP3,Q9BUG0, |
| UniProt Related Accession: | Q96RP3 |
| Molecular Weight: | Calculated: 12kDaObserved: Refer to figures |
| NCBI Full Name: | Urocortin-2 |
| NCBI Synonym Full Names: | urocortin 2 |
| NCBI Official Symbol: | UCN2 |
| NCBI Official Synonym Symbols: | UR; SRP; URP; UCNI; UCN-II |
| NCBI Protein Information: | urocortin-2; ucn II; urocortin II; prepro-urocortin 2; urocortin-related peptide; stresscopin-related peptide |
| UniProt Protein Name: | Urocortin-2 |
| UniProt Synonym Protein Names: | Stresscopin-related peptide; Urocortin II; Ucn II; Urocortin-related peptide |
| Protein Family: | Urocortin |
| UniProt Gene Name: | UCN2 |
| UniProt Entry Name: | UCN2_HUMAN |
 | Western blot analysis of extracts of rat skin, using UCN2 antibody (CAB6485) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse heart using UCN2 antibody (CAB6485) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using UCN2 antibody (CAB6485). Blue: DAPI for nuclear staining. |
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