Anti-TRPV2 Antibody (CAB12367)
- SKU:
- CAB12367
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TRPV2 Antibody |
| 抗体コード: | CAB12367 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 655-764 of human TRPV2 (NP_057197.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A375, SKOV3, 22Rv1, BxPC-3 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 655-764 of human TRPV2 (NP_057197.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DSWS IWKL QKAI SVLE MENG YWWC RKKQ RAGV MLTV GTKP DGSP DERW CFRV EEVN WASW EQTL PTLC EDPS GAGV PRTL ENPV LASP PKED EDGA SEEN YVPV QLLQ SN |
| 遺伝子ID: | 51393 |
| Uniprot: | Q9Y5S1 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Melanosome, Multi-pass membrane protein |
| 計算された分子量: | 85kDa |
| 観察された分子量: | 86kDa |
| 同義語: | TRPV2, VRL, VRL-1, VRL1 |
| バックグラウンド: | This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. |
| UniProt Protein Function: | TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Channel, cation; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: cell surface; integral to plasma membrane; plasma membrane; melanosome; endomembrane system Molecular Function:calcium channel activity; ion transmembrane transporter activity; ion channel activity; cation channel activity Biological Process: response to temperature stimulus; transport; response to heat; positive regulation of axon extension; sensory perception; transmembrane transport |
| NCBI Summary: | This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y5S1 |
| NCBI GenInfo Identifier: | 62901477 |
| NCBI Gene ID: | 51393 |
| NCBI Accession: | Q9Y5S1.1 |
| UniProt Secondary Accession: | Q9Y5S1,Q9Y670, A6NML2, A8K0Z0, |
| UniProt Related Accession: | Q9Y5S1 |
| Molecular Weight: | 85,981 Da |
| NCBI Full Name: | Transient receptor potential cation channel subfamily V member 2 |
| NCBI Synonym Full Names: | transient receptor potential cation channel, subfamily V, member 2 |
| NCBI Official Symbol: | TRPV2 |
| NCBI Official Synonym Symbols: | VRL; VRL1; VRL-1 |
| NCBI Protein Information: | transient receptor potential cation channel subfamily V member 2; OTRPC2; osm-9-like TRP channel 2; vanilloid receptor-like protein 1 |
| UniProt Protein Name: | Transient receptor potential cation channel subfamily V member 2 |
| UniProt Synonym Protein Names: | Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1 |
| Protein Family: | Transient receptor potential cation channel subfamily |
| UniProt Gene Name: | TRPV2 |
| UniProt Entry Name: | TRPV2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TRPV2 antibody (CAB12367) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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