Anti-TRIB2 Antibody (CAB11661)
- SKU:
- CAB11661
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TRIB2 Antibody |
| 抗体コード: | CAB11661 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human TRIB2 (NP_067675.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | K-562, 293T, Raji, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human TRIB2 (NP_067675.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNIH RSTP ITIA RYGR SRNK TQDF EELS SIRS AEPS QSFS PNLG SPSP PETP NLSH CVSC IGKY LLLE PLEG DHVF RAVH LHSG EELV CKVF DISC YQES LAPC FCLS AHSN INQI TEII |
| 遺伝子ID: | 28951 |
| Uniprot: | Q92519 |
| セルラーロケーション: | Cytoplasm, cytoskeleton |
| 計算された分子量: | 38kDa |
| 観察された分子量: | 49kDa |
| 同義語: | TRIB2, C5FW, GS3955, TRB2 |
| バックグラウンド: | This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. |
| UniProt Protein Function: | TRB2: Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. |
| UniProt Protein Details: | Protein type:CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family Chromosomal Location of Human Ortholog: 2p24.3 Cellular Component: cytoplasm; nucleus Molecular Function:mitogen-activated protein kinase kinase binding; nucleotide binding; protein kinase activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein ligase regulator activity Biological Process: negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of MAP kinase activity |
| NCBI Summary: | This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q92519 |
| NCBI GenInfo Identifier: | 74762638 |
| NCBI Gene ID: | 28951 |
| NCBI Accession: | Q92519.1 |
| UniProt Secondary Accession: | Q92519,B2R851, D6W510, |
| UniProt Related Accession: | Q92519 |
| Molecular Weight: | 39kDa |
| NCBI Full Name: | Tribbles homolog 2 |
| NCBI Synonym Full Names: | tribbles pseudokinase 2 |
| NCBI Official Symbol: | TRIB2 |
| NCBI Official Synonym Symbols: | C5FW; TRB2; GS3955 |
| NCBI Protein Information: | tribbles homolog 2 |
| UniProt Protein Name: | Tribbles homolog 2 |
| Protein Family: | Tribbles |
| UniProt Gene Name: | TRIB2 |
 | Western blot analysis of extracts of various cell lines, using TRIB2 antibody (CAB11661) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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