Anti-TRAF5 Antibody (CAB2536)
- SKU:
- CAB2536
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-TRAF5 Antibody |
| 抗体コード: | CAB2536 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human TRAF5 (NP_665702.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | OVCAR3 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human TRAF5 (NP_665702.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAYS EEHK GMPC GFIR QNSG NSIS LDFE PSIE YQFV ERLE ERYK CAFC HSVL HNPH QTGC GHRF CQHC ILSL RELN TVPI |
| 遺伝子ID: | 7188 |
| Uniprot: | O00463 |
| セルラーロケーション: | Cytoplasm, cytosol |
| 計算された分子量: | 52kDa/64kDa/65kDa |
| 観察された分子量: | 64kDa |
| 同義語: | TRAF5, MGC:39780, RNF84 |
| バックグラウンド: | The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | TRAF5: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Belongs to the TNF receptor-associated factor family. A subfamily. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1q32 Cellular Component: centrosome; internal side of plasma membrane; cytoplasm; cytosol Molecular Function:protein binding; signal transducer activity; zinc ion binding; thioesterase binding; ubiquitin protein ligase binding; ubiquitin-protein ligase activity Biological Process: regulation of apoptosis; positive regulation of I-kappaB kinase/NF-kappaB cascade; apoptosis; positive regulation of cell proliferation; protein ubiquitination; positive regulation of transcription factor activity; signal transduction; activation of NF-kappaB transcription factor |
| NCBI Summary: | The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | O00463 |
| NCBI GenInfo Identifier: | 30580600 |
| NCBI Gene ID: | 7188 |
| NCBI Accession: | O00463.2 |
| UniProt Related Accession: | O00463 |
| Molecular Weight: | Observed: 55 kDaPredicted: 65 kDa |
| NCBI Full Name: | TNF receptor-associated factor 5 |
| NCBI Synonym Full Names: | TNF receptor associated factor 5 |
| NCBI Official Symbol: | TRAF5 |
| NCBI Official Synonym Symbols: | RNF84; MGC:39780 |
| NCBI Protein Information: | TNF receptor-associated factor 5 |
| UniProt Protein Name: | TNF receptor-associated factor 5 |
| UniProt Synonym Protein Names: | RING finger protein 84 |
| Protein Family: | TNF receptor-associated factor |
| UniProt Gene Name: | TRAF5 |
| UniProt Entry Name: | TRAF5_HUMAN |
 | Western blot analysis of extracts of OVCAR3 cells, using TRAF5 antibody (CAB2536) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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