Anti-TNFRSF12A Antibody (RACO0266)
- SKU:
- RACO0266
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | TNFRSF12A Antibody |
| Product SKU: | RACO0266 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | WB:1:500-1:5000, IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human TWEAKR |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. |
| シノニム: | Tumor necrosis factor receptor superfamily member 12A (Fibroblast growth factor-inducible immediate-early response protein 14) (FGF-inducible 14) (Tweak-receptor) (TweakR) (CD antigen CD266), TNFRSF12A, FN14 |
 | IHC image of RACO0266 diluted at 1:100 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
 | Western Blot. Positive WB detected in U251 whole cell lysate MCF-7 whole cell lysate U87 whole cell lysate All lanes TNFRSF12A antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 14, 11 kD. Observed band size: 14 kDa. |
| UniProt Protein Function: | TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Cell development/differentiation; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane Molecular Function:protein binding Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; positive regulation of axon extension; angiogenesis; regulation of angiogenesis |
| UniProt Code: | Q9NP84 |
| NCBI GenInfo Identifier: | 21263626 |
| NCBI Gene ID: | 51330 |
| NCBI Accession: | Q9NP84.1 |
| UniProt Secondary Accession: | Q9NP84,Q9HCS0, D3DUA6, |
| UniProt Related Accession: | Q9NP84 |
| Molecular Weight: | 10,191 Da |
| NCBI Full Name: | Tumor necrosis factor receptor superfamily member 12A |
| NCBI Synonym Full Names: | tumor necrosis factor receptor superfamily, member 12A |
| NCBI Official Symbol: | TNFRSF12A |
| NCBI Official Synonym Symbols: | FN14; CD266; TWEAKR |
| NCBI Protein Information: | tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14 |
| UniProt Protein Name: | Tumor necrosis factor receptor superfamily member 12A |
| UniProt Synonym Protein Names: | Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD_antigen: CD266 |
| UniProt Gene Name: | TNFRSF12A |
| UniProt Entry Name: | TNR12_HUMAN |