Anti-TLN1 Antibody (CAB4158)
- SKU:
- CAB4158
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
抗体名: | Anti-TLN1 Antibody |
抗体コード: | CAB4158 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TLN1 (NP_006280.3). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human TLN1 (NP_006280.3). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MVAL SLKI SIGN VVKT MQFE PSTM VYDA CRII RERI PEAP AGPP SDFG LFLS DDDP KKGI WLEA GKAL DYYM LRNG DTME YRKK QRPL KIRM LDGT VKTI MVDD SKTV TDML MTIC ARIG ITNH DEYS LVRE LMEE KKEE ITGT LRKD KTLL RDEK KMEK LKQK LHTD DELN WLDH GRTL REQG VEEH ETLL LRRK FFYS DQNV DSRD PVQL NLLY VQAR |
遺伝子ID: | 7094 |
Uniprot: | Q9Y490 |
セルラーロケーション: | Cell junction, Cell projection, Cell surface, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cytoskeleton, focal adhesion, ruffle membrane |
計算された分子量: | 269kDa |
観察された分子量: | 240kDa |
同義語: | TLN1, ILWEQ, TLN, talin-1 |
バックグラウンド: | This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. |
UniProt Protein Function: | Talin-1: a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 9p13 Cellular Component: ruffle; cell surface; focal adhesion; cytoplasm; plasma membrane; extracellular region; microtubule organizing center; intercellular junction; cytosol Molecular Function:integrin binding; actin filament binding; LIM domain binding; protein binding; structural constituent of cytoskeleton; insulin receptor binding; vinculin binding Biological Process: platelet activation; intercellular junction assembly; axon guidance; unfolded protein response; cytoskeletal anchoring; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; platelet degranulation; muscle contraction; cell-substrate junction assembly; cortical actin cytoskeleton organization and biogenesis; cell motility; blood coagulation |
NCBI Summary: | This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009] |
UniProt Code: | Q9Y490 |
NCBI GenInfo Identifier: | 81175200 |
NCBI Gene ID: | 7094 |
NCBI Accession: | Q9Y490.3 |
UniProt Secondary Accession: | Q9Y490,Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3, A6NMY0, |
UniProt Related Accession: | Q9Y490 |
Molecular Weight: | 2541 |
NCBI Full Name: | Talin-1 |
NCBI Synonym Full Names: | talin 1 |
NCBI Official Symbol: | TLN1 |
NCBI Official Synonym Symbols: | TLN; ILWEQ |
NCBI Protein Information: | talin-1 |
UniProt Protein Name: | Talin-1 |
Protein Family: | Talin |
UniProt Gene Name: | TLN1 |
UniProt Entry Name: | TLN1_HUMAN |