Anti-TINAG Antibody (CAB17688)
- SKU:
- CAB17688
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-TINAG Antibody |
| 抗体コード: | CAB17688 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human TINAG (NP_055279.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-240 of human TINAG (NP_055279.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AIFQ GQYC RNFG CCED RDDG CVTE FYAA NALC YCDK FCDR ENSD CCPD YKSF CREE KEWP PHTQ PWYP EGCF KDGQ HYEE GSVI KENC NSCT CSGQ QWKC SQHV CLVR SELI EQVN KGDY GWTA QNYS QFWG MTLE DGFK FRLG TLPP SPML LSMN EMTA SLPA TTDL PEFF VASY KWPG WTHG PLDQ KNC |
| 遺伝子ID: | 27283 |
| Uniprot: | Q9UJW2 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | TIN-AG, TINAG |
| バックグラウンド: | This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011] |
| UniProt Protein Function: | TINAG: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 6p12.1 Cellular Component: basement membrane Molecular Function:cysteine-type endopeptidase activity; nucleotide binding; scavenger receptor activity; polysaccharide binding Biological Process: receptor-mediated endocytosis; immune response; proteolysis; cell adhesion |
| NCBI Summary: | This gene encodes a glycoprotein that is restricted within the kidney to the basement membranes underlying the epithelium of Bowman's capsule and proximal and distal tubules. Autoantibodies against this protein are found in sera of patients with tubulointerstital nephritis, membranous nephropathy and anti-glomerular basement membrane nephritis. Ontogeny studies suggest that the expression of this antigen is developmentally regulated in a precise spatial and temporal pattern throughout nephrogenesis. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9UJW2 |
| NCBI GenInfo Identifier: | 224586907 |
| NCBI Gene ID: | 27283 |
| NCBI Accession: | NP_055279.3 |
| UniProt Secondary Accession: | Q9UJW2,Q5T467, Q9UJW1, Q9ULZ4, |
| UniProt Related Accession: | Q9UJW2 |
| Molecular Weight: | 38,724 Da |
| NCBI Full Name: | tubulointerstitial nephritis antigen |
| NCBI Synonym Full Names: | tubulointerstitial nephritis antigen |
| NCBI Official Symbol: | TINAG |
| NCBI Official Synonym Symbols: | TIN-AG |
| NCBI Protein Information: | tubulointerstitial nephritis antigen |
| UniProt Protein Name: | Tubulointerstitial nephritis antigen |
| UniProt Gene Name: | TINAG |
| UniProt Entry Name: | TINAG_HUMAN |