Anti-TIAL1 Antibody (CAB6075)
- SKU:
- CAB6075
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-TIAL1 Antibody |
| 抗体コード: | CAB6075 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 266-375 of human TIAL1 (NP_003243.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, HeLa, K-562 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 266-375 of human TIAL1 (NP_003243.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EGHV VKCY WGKE SPDM TKNF QQVD YSQW GQWS QVYG NPQQ YGQY MANG WQVP PYGV YGQP WNQQ GFGV DQSP SAAW MGGF GAQP PQGQ APPP VIPP PNQA GYGM ASYQ TQ |
| 遺伝子ID: | 7073 |
| Uniprot: | Q01085 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic granule, Nucleus |
| 計算された分子量: | 41kDa/43kDa |
| 観察された分子量: | 47kDa |
| 同義語: | TIAL1, TCBP, TIAR |
| バックグラウンド: | The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. |
| UniProt Protein Function: | TIAL1: a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described. |
| UniProt Protein Details: | Protein type:RNA-binding; Apoptosis Chromosomal Location of Human Ortholog: 10q Cellular Component: stress granule; lysosome; cytoplasm; nucleus Molecular Function:RNA binding; nucleotide binding; AU-rich element binding Biological Process: regulation of transcription from RNA polymerase II promoter; apoptosis; stem cell division; positive regulation of cell proliferation; defense response; germ cell development |
| NCBI Summary: | The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q01085 |
| NCBI GenInfo Identifier: | 267131 |
| NCBI Gene ID: | 7073 |
| NCBI Accession: | Q01085.1 |
| UniProt Secondary Accession: | Q01085,P70318, |
| UniProt Related Accession: | Q01085 |
| Molecular Weight: | 375 |
| NCBI Full Name: | Nucleolysin TIAR |
| NCBI Synonym Full Names: | TIA1 cytotoxic granule-associated RNA binding protein-like 1 |
| NCBI Official Symbol: | TIAL1 |
| NCBI Official Synonym Symbols: | TCBP; TIAR |
| NCBI Protein Information: | nucleolysin TIAR; T-cluster binding protein; TIA-1-related nucleolysin; aging-associated gene 7 protein |
| UniProt Protein Name: | Nucleolysin TIAR |
| UniProt Synonym Protein Names: | TIA-1-related protein |
| UniProt Gene Name: | TIAL1 |
| UniProt Entry Name: | TIAR_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TIAL1 antibody (CAB6075) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat lung using TIAL1 antibody (CAB6075) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human appendix using TIAL1 antibody (CAB6075) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse spleen using TIAL1 antibody (CAB6075) at dilution of 1:100 (40x lens). |
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