Anti-TGM2 Antibody (RACO0343)
- SKU:
- RACO0343
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- WB
- Application:
- ELISA
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 商品名: | TGM2 Antibody |
| Product SKU: | RACO0343 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:5000 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human TGM2 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. |
| シノニム: | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Tissue transglutaminase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase-2) (TGase-2), TGM2 |
 | Western Blot. Positive WB detected in U87 whole cell lysate All lanes TGM2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1:50000 dilution. Predicted band size: 78, 62, 39 kDa. Observed band size: 78 kDa. |
| UniProt Protein Function: | TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis.. Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:EC 2.3.2.13; Transferase Chromosomal Location of Human Ortholog: 20q12 Cellular Component: cytosol; focal adhesion; intrinsic to plasma membrane; mitochondrion Molecular Function:protein binding; protein-glutamine gamma-glutamyltransferase activity Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration |
| NCBI Summary: | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P21980 |
| NCBI GenInfo Identifier: | 20141877 |
| NCBI Gene ID: | 7052 |
| NCBI Accession: | P21980.2 |
| UniProt Secondary Accession: | P21980,Q16436, Q6B838, Q9BTN7, Q9UH35, E1P5V9, |
| UniProt Related Accession: | P21980 |
| Molecular Weight: | 38,671 Da |
| NCBI Full Name: | Protein-glutamine gamma-glutamyltransferase 2 |
| NCBI Synonym Full Names: | transglutaminase 2 |
| NCBI Official Symbol: | TGM2 |
| NCBI Official Synonym Symbols: | TGC; TG(C) |
| NCBI Protein Information: | protein-glutamine gamma-glutamyltransferase 2 |
| UniProt Protein Name: | Protein-glutamine gamma-glutamyltransferase 2 |
| UniProt Synonym Protein Names: | Tissue transglutaminase; Transglutaminase C; TG(C); TGC; TGase C; Transglutaminase H; TGase H; Transglutaminase-2; TGase-2 |
| Protein Family: | Protein-glutamine gamma-glutamyltransferase |
| UniProt Gene Name: | TGM2 |
| UniProt Entry Name: | TGM2_HUMAN |