Anti-TFR2 Antibody (CAB9845)
- SKU:
- CAB9845
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TFR2 Antibody |
| 抗体コード: | CAB9845 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 582-801 of human TFR2 (NP_003218.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse kidney, Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 582-801 of human TFR2 (NP_003218.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AVEF SFME DDQA YPFL HTKE DTYE NLHK VLQG RLPA VAQA VAQL AGQL LIRL SHDR LLPL DFGR YGDV VLRH IGNL NEFS GDLK ARGL TLQW VYSA RGDY IRAA EKLR QEIY SSEE RDER LTRM YNVR IMRV EFYF LSQY VSPA DSPF RHIF MGRG DHTL GALL DHLR LLRS NSSG TPGA TSST GFQE SRFR RQLA LLTW TLQG AANA LSGD VWNI DNNF |
| 遺伝子ID: | 7036 |
| Uniprot: | Q9UP52 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Single-pass type II membrane protein |
| 計算された分子量: | 69kDa/86kDa/88kDa |
| 観察された分子量: | 89kDa |
| 同義語: | TFR2, HFE3, TFRC2 |
| バックグラウンド: | This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | TFR2: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Defects in TFR2 are a cause of hemochromatosis type 3 (HFE3). HFE3 is a disorder of iron hemostasis resulting in iron overload and has a phenotype indistinguishable from that of hereditary hemochromatosis (HH). HH is characterized by abnormal intestinal iron absorption and progressive increase of total body iron, which results in midlife in clinical complications including cirrhosis, cardiopathy, diabetes, endocrine dysfunctions, arthropathy, and susceptibility to liver cancer. Since the disease complications can be effectively prevented by regular phlebotomies, early diagnosis is most important to provide a normal life expectancy to the affected subjects. Belongs to the peptidase M28 family. M28B subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q22 Cellular Component: cytoplasmic vesicle; external side of plasma membrane; integral to plasma membrane Molecular Function:glycoprotein binding; protein binding; transferrin receptor activity Biological Process: cellular iron ion homeostasis; iron ion homeostasis; positive regulation of endocytosis; positive regulation of transcription from RNA polymerase II promoter; receptor-mediated endocytosis; response to iron ion; transferrin transport Disease: Hemochromatosis, Type 3 |
| NCBI Summary: | This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | Q9UP52 |
| NCBI GenInfo Identifier: | 20140912 |
| NCBI Gene ID: | 7036 |
| NCBI Accession: | Q9UP52.1 |
| UniProt Secondary Accession: | Q9UP52,O75422, Q1HE13, Q9HA99, Q9NX67, A6NGM7, |
| UniProt Related Accession: | Q9UP52 |
| Molecular Weight: | |
| NCBI Full Name: | Transferrin receptor protein 2 |
| NCBI Synonym Full Names: | transferrin receptor 2 |
| NCBI Official Symbol: | TFR2 |
| NCBI Official Synonym Symbols: | HFE3; TFRC2 |
| NCBI Protein Information: | transferrin receptor protein 2 |
| UniProt Protein Name: | Transferrin receptor protein 2 |
| Protein Family: | Transferrin receptor protein |
| UniProt Gene Name: | TFR2 |
| UniProt Entry Name: | TFR2_HUMAN |
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