| UniProt Protein Function: | TFAM: regulates mitochondrial transcription. Induced in humans by caloric restriction. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Activates transcription by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Involved in cisplatin resistance. Interacts with TFB1M and TFB2M. |
| UniProt Protein Details: | Protein type:Transcription regulation; DNA-binding Chromosomal Location of Human Ortholog: 10q21 Cellular Component: mitochondrion; mitochondrial matrix; nucleus; cytosol Molecular Function:protein binding; heat shock protein binding; chromatin binding; transcription factor activity; DNA bending activity Biological Process: mitochondrial respiratory chain complex assembly; chromatin remodeling; mitochondrion organization and biogenesis; regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent; organelle organization and biogenesis; gene expression; positive regulation of transcription from RNA polymerase II promoter; DNA-dependent DNA replication; transcription from mitochondrial promoter; transcription initiation from mitochondrial promoter |
| NCBI Summary: | This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
| UniProt Code: | Q00059 |
| NCBI GenInfo Identifier: | 417324 |
| NCBI Gene ID: | 7019 |
| NCBI Accession: | Q00059.1 |
| UniProt Secondary Accession: | Q00059,Q5U0C6, A8MRB2, A9QXC6, B5BU05, |
| UniProt Related Accession: | Q00059 |
| Molecular Weight: | 246 |
| NCBI Full Name: | Transcription factor A, mitochondrial |
| NCBI Synonym Full Names: | transcription factor A, mitochondrial |
| NCBI Official Symbol: | TFAM |
| NCBI Official Synonym Symbols: | TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3 |
| NCBI Protein Information: | transcription factor A, mitochondrial; transcription factor 6; transcription factor 6-like 1; transcription factor 6-like 3; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcription factor 6-like 2 (mitochondrial transcription factor) |
| UniProt Protein Name: | Transcription factor A, mitochondrial |
| UniProt Synonym Protein Names: | Mitochondrial transcription factor 1; MtTF1; Transcription factor 6; TCF-6; Transcription factor 6-like 2 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | TFAM |
| UniProt Entry Name: | TFAM_HUMAN |
