Anti-TCAP Antibody (CAB6765)
- SKU:
- CAB6765
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-TCAP Antibody |
| 抗体コード: | CAB6765 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_003664.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse heart, Mouse skeletal muscle, Rat heart, Rat skeletal muscle, Rat skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-167 of human TCAP (NP_003664.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MATS ELSC EVSE ENCE RREA FWAE WKDL TLST RPEE GCSL HEED TQRH ETYH QQGQ CQVL VQRS PWLM MRMG ILGR GLQE YQLP YQRV LPLP IFTP AKMG ATKE ERED TPIQ LQEL LALE TALG GQCV DRQE VAEI TKQL PPVV PVSK PGAL RRSL SRSM SQEA QRG |
| 遺伝子ID: | 8557 |
| Uniprot: | O15273 |
| セルラーロケーション: | Cytoplasm, myofibril, sarcomere |
| 計算された分子量: | 19kDa |
| 観察された分子量: | 19kDa |
| 同義語: | TCAP, CMD1N, CMH25, LGMD2G, T-cap, TELE, telethonin, titin-cap |
| バックグラウンド: | Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. |
| UniProt Protein Function: | Telethonin: a muscle assembly regulating factor that interacts with the giant kinase titin. Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. Telethonin is found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q12 Cellular Component: I band; cytosol; Z disc Molecular Function:protein binding, bridging; protein binding; structural constituent of muscle; titin binding; FATZ binding Biological Process: adult heart development; skeletal muscle contraction; cardiac muscle hypertrophy; somitogenesis; muscle thin filament assembly; detection of mechanical stimulus; cardiac myofibril assembly; sarcomere organization; muscle filament sliding; muscle thick filament assembly; cardiac muscle fiber development; cardiac muscle morphogensis; sarcomerogenesis; protein complex assembly; otic vesicle formation; cardiac muscle contraction Disease: Muscular Dystrophy, Limb-girdle, Type 2g; Cardiomyopathy, Dilated, 1n |
| NCBI Summary: | Sarcomere assembly is regulated by the muscle protein titin. Titin is a giant elastic protein with kinase activity that extends half the length of a sarcomere. It serves as a scaffold to which myofibrils and other muscle related proteins are attached. This gene encodes a protein found in striated and cardiac muscle that binds to the titin Z1-Z2 domains and is a substrate of titin kinase, interactions thought to be critical to sarcomere assembly. Mutations in this gene are associated with limb-girdle muscular dystrophy type 2G. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15273 |
| NCBI GenInfo Identifier: | 3024716 |
| NCBI Gene ID: | 8557 |
| NCBI Accession: | O15273.1 |
| UniProt Secondary Accession: | O15273,Q96L27, |
| UniProt Related Accession: | O15273 |
| Molecular Weight: | Observed MW: 19kDaCalculated MW: 19kDa |
| NCBI Full Name: | Telethonin |
| NCBI Synonym Full Names: | titin-cap |
| NCBI Official Symbol: | TCAP |
| NCBI Official Synonym Symbols: | TELE; CMD1N; T-cap; LGMD2G; telethonin |
| NCBI Protein Information: | telethonin; titin cap protein; 19 kDa sarcomeric protein; limb girdle muscular dystrophy 2G (autosomal recessive) |
| UniProt Protein Name: | Telethonin |
| UniProt Synonym Protein Names: | Titin cap protein |
| Protein Family: | Telethonin |
| UniProt Gene Name: | TCAP |
| UniProt Entry Name: | TELT_HUMAN |
 | Western blot analysis of extracts of various cell lines, using TCAP antibody (CAB6765) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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