Anti-TBX19 Antibody (CAB10481)
- SKU:
- CAB10481
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-TBX19 Antibody |
| 抗体コード: | CAB10481 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 229-448 of human TBX19 (NP_005140.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 229-448 of human TBX19 (NP_005140.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PEAI SESQ HVTY SHLG GWIF SNPD GVCT AGNS NYQY AAPL PLPA PHTH HGCE HYSG LRGH RQAP YPSA YMHR NHSP SVNL IESS SNNL QVFS GPDS WTSL SSTP HASI LSVP HTNG PINP GPSP YPCL WTIS NGAG GPSG PGPE VHAS TPGA FLLG NPAV TSPP SVLS TQAP TSAG VEVL GEPS LTSI AVST WTAV ASHP FAGW GGPG AGGH HSPS SLDG |
| 遺伝子ID: | 9095 |
| Uniprot: | O60806 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 48kDa |
| 観察された分子量: | 48kDa |
| 同義語: | TBX19, TBS19, TPIT, dJ747L4.1, T-box 19 |
| バックグラウンド: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. |
| UniProt Protein Function: | TBX19: Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters. Defects in TBX19 are a cause of ACTH deficiency isolated (IAD). ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure (hypotension). The pituitary hormone ACTH is decreased or absent, and other cortisol and other steroid hormone levels in the blood are abnormally low. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 1q24.2 Biological Process: anatomical structure morphogenesis; regulation of transcription from RNA polymerase II promoter Disease: Acth Deficiency, Isolated |
| NCBI Summary: | This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60806 |
| NCBI GenInfo Identifier: | 6226281 |
| NCBI Gene ID: | 9095 |
| NCBI Accession: | O60806.3 |
| UniProt Secondary Accession: | O60806,Q52M53, |
| UniProt Related Accession: | O60806 |
| Molecular Weight: | 48kDa |
| NCBI Full Name: | T-box transcription factor TBX19 |
| NCBI Synonym Full Names: | T-box 19 |
| NCBI Official Symbol: | TBX19 |
| NCBI Official Synonym Symbols: | TPIT; TBS19; dJ747L4.1 |
| NCBI Protein Information: | T-box transcription factor TBX19 |
| UniProt Protein Name: | T-box transcription factor TBX19 |
| UniProt Synonym Protein Names: | T-box factor, pituitary |
| Protein Family: | T-box transcription factor |
| UniProt Gene Name: | TBX19 |
 | Western blot analysis of extracts of 293T cells, using TBX19 antibody (CAB10481) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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