Anti-TAS2R38 Antibody (CAB15087)
- SKU:
- CAB15087
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-TAS2R38 Antibody |
| 抗体コード: | CAB15087 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TAS2R38 (NP_789787.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | rat thymus |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TAS2R38 (NP_789787.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CSCI CTVL CVWC FFSR PHFT VTTV LFMN NNTR LNWQ IKDL NLFY SFLF CYLW SVPP FLLF LVSS GMLT VSLG RHMR TMKV YTRN SRDP SLEA HIKA LKSL V |
| 遺伝子ID: | 5726 |
| Uniprot: | P59533 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 38kDa |
| 同義語: | TAS2R38, PTC, T2R38, T2R61 |
| バックグラウンド: | This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). |
| UniProt Protein Function: | TAS2R38: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Belongs to the G-protein coupled receptor T2R family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; GPCR, T2R family; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q34 Cellular Component: integral to membrane; plasma membrane Molecular Function:bitter taste receptor activity Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste Disease: Thiourea Tasting |
| NCBI Summary: | This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009] |
| UniProt Code: | P59533 |
| NCBI GenInfo Identifier: | 68068016 |
| NCBI Gene ID: | 5726 |
| NCBI Accession: | P59533.3 |
| UniProt Secondary Accession: | P59533,P59552, Q2M3E8, Q645W3, Q86UK3, A4D1U6, |
| UniProt Related Accession: | P59533 |
| Molecular Weight: | 37,892 Da |
| NCBI Full Name: | Taste receptor type 2 member 38 |
| NCBI Synonym Full Names: | taste 2 receptor member 38 |
| NCBI Official Symbol: | TAS2R38 |
| NCBI Official Synonym Symbols: | PTC; T2R38; T2R61 |
| NCBI Protein Information: | taste receptor type 2 member 38 |
| UniProt Protein Name: | Taste receptor type 2 member 38 |
| UniProt Synonym Protein Names: | PTC bitter taste receptor; Taste receptor type 2 member 61; T2R61 |
| Protein Family: | Taste receptor |
| UniProt Gene Name: | TAS2R38 |
| UniProt Entry Name: | T2R38_HUMAN |
 | Western blot analysis of extracts of rat thymus, using TAS2R38 antibody (CAB15087) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90. |
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