Anti-SWAP70 Antibody (CAB14857)

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SKU:
CAB14857
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
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Description

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抗体名:Anti-SWAP70 Antibody
抗体コード:CAB14857
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB IHC IF
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 316-585 of human SWAP70 (NP_055870.2).
申し込み:WB IHC IF
推奨希釈:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
反応性:Human, Mouse, Rat
ポジティブサンプル:293T, A-549, LO2
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 316-585 of human SWAP70 (NP_055870.2).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:HKEA RQRR KELR KKQL AEQE ELER QMKE LQAA NESK QQEL EAVR KKLE EAAS RAAE EEKK RLQT QVEL QARF STEL EREK LIRQ QMEE QVAQ KSSE LEQY LQRV RELE DMYL KLQE ALED ERQA RQDE ETVR KLQA RLLE EESS KRAE LEKW HLEQ QQAI QTTE AEKQ ELEN QRVL KEQA LQEA MEQL EQLE LERK QALE QYEE VKKK LEMA TNKT KSWK DKVA HHEG LIRL IEPG SKNP HLIT NWGP AAFT EAEL EERE KNWK EKKT TE
遺伝子ID:23075
Uniprot:Q9UH65
セルラーロケーション:Cell membrane, Cell projection, Cytoplasm, Nucleus, lamellipodium
計算された分子量:68kDa
観察された分子量:69kDa
同義語:SWAP70, HSPC321, SWAP-70
バックグラウンド:
UniProt Protein Function:SWAP-70: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
UniProt Protein Details:

Protein type:GEF; GEF, Rac/Rho

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: cell-cell adherens junction; cytoplasm

Molecular Function:protein binding

UniProt Code:Q9UH65
NCBI GenInfo Identifier:74753323
NCBI Gene ID:23075
NCBI Accession:Q9UH65.1
UniProt Secondary Accession:Q9UH65,O75135, Q7LCY6, Q9P061, Q9P0Z8, D3DQV1,
UniProt Related Accession:Q9UH65
Molecular Weight:68,998 Da
NCBI Full Name:Switch-associated protein 70
NCBI Synonym Full Names:SWAP switching B-cell complex subunit 70
NCBI Official Symbol:SWAP70  
NCBI Official Synonym Symbols:HSPC321; SWAP-70  
NCBI Protein Information:switch-associated protein 70
UniProt Protein Name:Switch-associated protein 70
Protein Family:Switch-associated protein
UniProt Gene Name:SWAP70  
Anti-SWAP70 Antibody (CAB14857)Western blot analysis of extracts of various cell lines, using SWAP70 antibody (CAB14857) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-SWAP70 Antibody (CAB14857)Immunohistochemistry of paraffin-embedded Mouse spleen using SWAP70 Rabbit pAb (CAB14857) at dilution of 1:100 (40x lens).
Anti-SWAP70 Antibody (CAB14857)Immunohistochemistry of paraffin-embedded Rat spleen using SWAP70 Rabbit pAb (CAB14857) at dilution of 1:100 (40x lens).
Anti-SWAP70 Antibody (CAB14857)Immunohistochemistry of paraffin-embedded Human lung using SWAP70 Rabbit pAb (CAB14857) at dilution of 1:100 (40x lens).
Anti-SWAP70 Antibody (CAB14857)Immunofluorescence analysis of L929 cells using SWAP70 antibody (CAB14857) at dilution of 1:100. Blue: DAPI for nuclear staining.
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