Anti-STXBP5 Antibody (CAB16311)
- SKU:
- CAB16311
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-STXBP5 Antibody |
| 抗体コード: | CAB16311 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-900 of human STXBP5 (NP_640337.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-900 of human STXBP5 (NP_640337.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SYGL VVFG NCNG IAMV DYLQ KAVL LNLG TIEL YGSN DPYR REPR SPRK SRQP SGAG LCDI SEGT VVPE DRCK SPTS AKMS RKLS LPTD LKPD LDVK DNSF SRSR SSSV TSID KESR EAIS ALHF CETF TRKT DSSP SPCL WVGT TLGT VLVI ALNL PPGG EQRL LQPV IVSP SGTI LRLK GAIL RMAF LDTT GCLI PPAY EPWR EHNV PEEK DEKE KLKK RRPV SVSP SSSQ EISE NQYA VICS EKQA KVIS LPTQ NCAY K |
| 遺伝子ID: | 134957 |
| Uniprot: | Q5T5C0 |
| セルラーロケーション: | |
| 計算された分子量: | 121kDa/123kDa/127kDa |
| 観察された分子量: | 135kDa |
| 同義語: | STXBP5, LGL3, LLGL3, Nbla04300 |
| バックグラウンド: | Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | STXBP5: Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding. Belongs to the WD repeat L(2)GL family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 6q24.3 Cellular Component: cytoplasm; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; secretory granule; SNARE complex Molecular Function:GTPase activator activity; Rab GTPase binding; syntaxin binding; syntaxin-1 binding Biological Process: positive regulation of exocytosis; regulation of blood coagulation; regulation of exocytosis; regulation of gene expression; regulation of protein secretion |
| NCBI Summary: | Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q5T5C0 |
| NCBI GenInfo Identifier: | 109730460 |
| NCBI Gene ID: | 134957 |
| NCBI Accession: | BC113408 |
| UniProt Secondary Accession: | Q5T5C0,Q14DF3, Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9, |
| UniProt Related Accession: | Q5T5C0 |
| Molecular Weight: | 121,597 Da |
| NCBI Full Name: | Homo sapiens syntaxin binding protein 5 (tomosyn), mRNA |
| NCBI Synonym Full Names: | syntaxin binding protein 5 |
| NCBI Official Symbol: | STXBP5 |
| NCBI Official Synonym Symbols: | LGL3; LLGL3; Nbla04300 |
| NCBI Protein Information: | syntaxin-binding protein 5 |
| UniProt Protein Name: | Syntaxin-binding protein 5 |
| UniProt Synonym Protein Names: | Lethal(2) giant larvae protein homolog 3; Tomosyn-1 |
| Protein Family: | Syntaxin-binding protein |
| UniProt Gene Name: | STXBP5 |
| UniProt Entry Name: | STXB5_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using STXBP5 antibody (CAB16311) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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