Anti-STK25 Antibody (CAB9726)
- SKU:
- CAB9726
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-STK25 Antibody |
| 抗体コード: | CAB9726 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-426 of human STK25 (NP_006365.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | SW620, Mouse small intestine |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 297-426 of human STK25 (NP_006365.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EESS SEDS DIDG EAED GEQG PIWT FPPT IRPS PHSK LHKG TALH SSQK PAEP VKRQ PRSQ CLST LVRP VFGE LKEK HKQS GGSV GALE ELEN AFSL AEES CPGI SDKL MVHL VERV QRFS HNRN HLTS TR |
| 遺伝子ID: | 10494 |
| Uniprot: | O00506 |
| セルラーロケーション: | Cytoplasm, Golgi apparatus |
| 計算された分子量: | 37kDa/39kDa/48kDa |
| 観察された分子量: | 48kDa |
| 同義語: | STK25, SOK1, YSK1 |
| バックグラウンド: | This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. |
| UniProt Protein Function: | YSK1: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. |
| UniProt Protein Details: | Protein type:Protein kinase, STE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; STE group; STE20 family; YSK subfamily Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: cytoplasm; Golgi apparatus Molecular Function:protein binding; protein homodimerization activity; protein kinase activity; receptor signaling protein serine/threonine kinase activity Biological Process: establishment of Golgi localization; Golgi localization; positive regulation of stress-activated MAPK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; response to hydrogen peroxide; response to oxidative stress; signal transduction |
| NCBI Summary: | This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | O00506 |
| NCBI GenInfo Identifier: | 12643529 |
| NCBI Gene ID: | 10494 |
| NCBI Accession: | O00506.1 |
| UniProt Secondary Accession: | O00506,Q15522, Q5BJF1, A8K6Z3, A8K7D2, B7Z9K1, |
| UniProt Related Accession: | O00506 |
| Molecular Weight: | 37,297 Da |
| NCBI Full Name: | Serine/threonine-protein kinase 25 |
| NCBI Synonym Full Names: | serine/threonine kinase 25 |
| NCBI Official Symbol: | STK25 |
| NCBI Official Synonym Symbols: | SOK1; YSK1 |
| NCBI Protein Information: | serine/threonine-protein kinase 25 |
| UniProt Protein Name: | Serine/threonine-protein kinase 25 |
| UniProt Synonym Protein Names: | Ste20-like kinase; Sterile 20/oxidant stress-response kinase 1; SOK-1; Ste20/oxidant stress response kinase 1 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | STK25 |
| UniProt Entry Name: | STK25_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STK25 antibody (CAB9726) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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