Anti-STIP1 Antibody (CAB14106)
- SKU:
- CAB14106
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Reactivity:
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-STIP1 Antibody |
| 抗体コード: | CAB14106 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF IP |
| 反応性: | Human, Mouse, Rat, Monkey |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human STIP1 (NP_006810.1). |
| 申し込み: | WB IHC IF IP |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:20 - 1:50 |
| 反応性: | Human, Mouse, Rat, Monkey |
| ポジティブサンプル: | HeLa, COS-7, COS-1, OVCAR3, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human STIP1 (NP_006810.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEQV NELK EKGN KALS VGNI DDAL QCYS EAIK LDPH NHVL YSNR SAAY AKKG DYQK AYED GCKT VDLK PDWG KGYS RKAA ALEF LNRF EEAK RTYE EGLK HEAN NPQL KEGL QNME ARLA ERKF MNPF NMPN LYQK LESD PRTR TLLS DPTY RELI EQLR NKPS DLGT KLQD PRIM TTLS VLLG VDLG SMDE EEEI ATPP PPPP PKKE TKPE PMEE DLPE NKKQ ALKE KELG NDAY KKKD FDTA LKHY DKAK ELDP TNMT YITN QAAV YFEK GDYN KCRE LCEK AIEV GREN REDY RQIA |
| 遺伝子ID: | 10963 |
| Uniprot: | P31948 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 59kDa/62kDa/68kDa |
| 観察された分子量: | 69kDa |
| 同義語: | STIP1, HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L |
| バックグラウンド: |
| UniProt Protein Function: | STI1: a protein that is apparently involved in the response to stress. Specifically interacts with the C-terminal tails of Hsp70 and Hsp90 via TPR1 and TPR2A domains. Deletion of STI1 reduces the activity of the glucocorticoid receptor, a Hsp90 target protein. Phosphorylated in vitro by p90RSK and casein kinase II. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi apparatus; nucleus Molecular Function:protein binding Biological Process: response to stress |
| NCBI Summary: | STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009] |
| UniProt Code: | P31948 |
| NCBI GenInfo Identifier: | 400042 |
| NCBI Gene ID: | 10963 |
| NCBI Accession: | P31948.1 |
| UniProt Secondary Accession: | P31948,Q3ZCU9, Q5TZU9, B4DM70, F5H0T1, G3XAD8, |
| UniProt Related Accession: | P31948 |
| Molecular Weight: | 543 |
| NCBI Full Name: | Stress-induced-phosphoprotein 1 |
| NCBI Synonym Full Names: | stress-induced phosphoprotein 1 |
| NCBI Official Symbol: | STIP1 |
| NCBI Official Synonym Symbols: | HOP; P60; STI1; STI1L; HEL-S-94n; IEF-SSP-3521 |
| NCBI Protein Information: | stress-induced-phosphoprotein 1; NY-REN-11 antigen; Hsp70/Hsp90-organizing protein; hsc70/Hsp90-organizing protein; renal carcinoma antigen NY-REN-11; transformation-sensitive protein IEF SSP 3521; epididymis secretory sperm binding protein Li 94n |
| UniProt Protein Name: | Stress-induced-phosphoprotein 1 |
| UniProt Synonym Protein Names: | Hsc70/Hsp90-organizing protein; Hop; Renal carcinoma antigen NY-REN-11; Transformation-sensitive protein IEF SSP 3521 |
| Protein Family: | STIP1 homology and U box-containing protein |
| UniProt Gene Name: | STIP1 |
| UniProt Entry Name: | STIP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using STIP1 antibody (CAB14106) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded rat testis using STIP1 Rabbit pAb (CAB14106) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse testis using STIP1 Rabbit pAb (CAB14106) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using STIP1 antibody (CAB14106). Blue: DAPI for nuclear staining. |
 | Immunoprecipitation analysis of 200ug extracts of HeLa cells using 1ug STIP1 antibody ( A14106). Western blot was performed from the immunoprecipitate using STIP1 antibody ( A14106) at a dilition of 1:1000. |
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