Anti-STEAP3 Antibody (CAB0683)
- SKU:
- CAB0683
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-STEAP3 Antibody |
| 抗体コード: | CAB0683 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STEAP3 (NP_060704.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human STEAP3 (NP_060704.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPEE MDKP LISL HLVD SDSS LAKV PDEA PKVG ILGS GDFA RSLA TRLV GSGF KVVV GSRN PKRT ARLF PSAA QVTF QEEA VSSP EVIF VAVF REHY SSLC SLSD QLAG KILV DVSN PTEQ EHLQ HRES NAEY LASL FPTC TVVK AFNV ISAW TLQA GPRD GNRQ VPIC GDQP EAKR AVSE |
| 遺伝子ID: | 55240 |
| Uniprot: | Q658P3 |
| セルラーロケーション: | Endosome membrane, Multi-pass membrane protein |
| 計算された分子量: | 50kDa/54kDa/55kDa |
| 観察された分子量: | 55kDa |
| 同義語: | STEAP3, AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde |
| バックグラウンド: | This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | STEAP3: a multi-pass membrane protein induced directly by p53. Plays an important role in facilitating exosome secretion. Enhances secretion in the DNA damage-induced p53-dependent exosomal secretory pathway. Localizes to vesicular-like structures at the plasma membrane and around the nucleus. Highly expressed in hematopoietic tissues where it localizes to the specialized endosome. An endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor. Contains a highly-conserved tyrosine-based motif that has been shown to target transmembrane proteins, including LAMP-1, LAMP-2, the TfR, and SLC11A1 to endosomes, lysosomes, and lysosome-related organelles. Facilitates the exosomal secretion of proteins such as TCTP. Interacts with BNIP3L, MYT1 and TPT1. Four human isoforms are produced by alternative splicing. Isoform 4 is also known as pHyde II. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; EC 1.16.1.-; Transporter, iron; Transporter, ion channel; Oxidoreductase; Transporter Chromosomal Location of Human Ortholog: 2q14.2 Cellular Component: multivesicular body; integral to membrane; plasma membrane; endosome membrane Molecular Function:protein binding; metal ion binding; cupric reductase activity; ferric-chelate reductase activity Biological Process: apoptosis; cellular iron ion homeostasis; protein secretion; transferrin transport; copper ion import; cell cycle; transmembrane transport Disease: Anemia, Hypochromic Microcytic, With Iron Overload 2 |
| NCBI Summary: | This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
| UniProt Code: | Q658P3 |
| NCBI GenInfo Identifier: | 146325737 |
| NCBI Gene ID: | 55240 |
| NCBI Accession: | Q658P3.2 |
| UniProt Secondary Accession: | Q658P3,Q4VBR2, Q4ZG36, Q53SQ8, Q7Z389, Q86SF6, Q8NEW6 Q8TDP3, Q8TF03, Q9NVB5, A8K6E3, |
| UniProt Related Accession: | Q658P3 |
| Molecular Weight: | 488 |
| NCBI Full Name: | Metalloreductase STEAP3 |
| NCBI Synonym Full Names: | STEAP family member 3, metalloreductase |
| NCBI Official Symbol: | STEAP3 |
| NCBI Official Synonym Symbols: | STMP3; TSAP6; AHMIO2; dudlin-2 |
| NCBI Protein Information: | metalloreductase STEAP3; pHyde; hTSAP6; hpHyde; dudlin 2; dudulin 2; dudulin-2; 1010001D01Rik; tumor suppressor pHyde; six transmembrane prostate protein 3; tumor suppressor-activated pathway protein 6; six-transmembrane epithelial antigen of prostate 3 |
| UniProt Protein Name: | Metalloreductase STEAP3 |
| UniProt Synonym Protein Names: | Dudulin-2; Six-transmembrane epithelial antigen of prostate 3; Tumor suppressor-activated pathway protein 6; hTSAP6; pHyde; hpHyde |
| Protein Family: | Metalloreductase |
| UniProt Gene Name: | STEAP3 |
| UniProt Entry Name: | STEA3_HUMAN |
 | Western blot analysis of extracts of mouse heart, using STEAP3 antibody (CAB0683) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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