Anti-SRI Antibody (CAB6751)
- SKU:
- CAB6751
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-SRI Antibody |
| 抗体コード: | CAB6751 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SRI (NP_003121.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, MCF7, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human SRI (NP_003121.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAYP GHPG AGGG YYPG GYGG APGG PAFP GQTQ DPLY GYFA AVAG QDGQ IDAD ELQR CLTQ SGIA GGYK PFNL ETCR LMVS MLDR DMSG TMGF NEFK ELWA VLNG WRQH FISF DTDR SGTV DPQE LQKA LTTM GFRL SPQA VNSI AKRY STNG KITF DDYI ACCV KLRA LTDS FRRR DTAQ QGVV NFPY DDFI QCVM SV |
| 遺伝子ID: | 6717 |
| Uniprot: | P30626 |
| セルラーロケーション: | Cytoplasm, Cytoplasmic side, Peripheral membrane protein, Sarcoplasmic reticulum membrane |
| 計算された分子量: | 20kDa/21kDa |
| 観察された分子量: | 22kDa |
| 同義語: | SRI, CP-22, CP22, SCN, V19, sorcin |
| バックグラウンド: | This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. |
| UniProt Protein Function: | SRI: Calcium-binding protein that modulates excitation- contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 7q21.1 Cellular Component: nucleoplasm; endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; smooth endoplasmic reticulum; membrane; mitochondrion; sarcoplasmic reticulum; T-tubule; cytoplasm; nerve terminal; cytosol; Z disc Molecular Function:protein binding; protease binding; protein heterodimerization activity; calcium channel regulator activity; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding; receptor binding Biological Process: regulation of action potential; cytoplasmic sequestering of transcription factor; muscle development; negative regulation of heart rate; heart development; regulation of striated muscle contraction; regulation of calcium ion transport; proteolysis; signal transduction; regulation of heart contraction; transport; calcium ion transport; positive regulation of release of sequestered calcium ion into cytosol; intracellular sequestering of iron ion |
| NCBI Summary: | This gene encodes a calcium-binding protein with multiple E-F hand domains that relocates from the cytoplasm to the sarcoplasmic reticulum in response to elevated calcium levels. In addition to regulating intracellular calcium homeostasis it also modulates excitation-contraction coupling in the heart. Alternative splicing results in multiple transcript variants encoding distinct proteins. Multiple pseudogenes exist for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P30626 |
| NCBI GenInfo Identifier: | 267021 |
| NCBI Gene ID: | 6717 |
| NCBI Accession: | P30626.1 |
| UniProt Secondary Accession: | P30626,A8MTH6, B4DKK2, D6W5Q0, |
| UniProt Related Accession: | P30626 |
| Molecular Weight: | 198 |
| NCBI Full Name: | Sorcin |
| NCBI Synonym Full Names: | sorcin |
| NCBI Official Symbol: | SRI |
| NCBI Official Synonym Symbols: | SCN; V19; CP22; CP-22 |
| NCBI Protein Information: | sorcin; H_RG167B05.1; 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells |
| UniProt Protein Name: | Sorcin |
| UniProt Synonym Protein Names: | 22 kDa protein; CP-22; CP22; V19 |
| UniProt Gene Name: | SRI |
| UniProt Entry Name: | SORCN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SRI Antibody (CAB6751) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using SRI antibody (CAB6751) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using SRI antibody (CAB6751) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using SRI antibody (CAB6751) at dilution of 1:100 (40x lens). |