Anti-SRCAP Antibody (CAB17933)
- SKU:
- CAB17933
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-SRCAP Antibody |
| 抗体コード: | CAB17933 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SRCAP. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human SRCAP. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 10847 |
| Uniprot: | Q6ZRS2 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | DOMO1, EAF1, FLHS, SWR1, SRCAP |
| バックグラウンド: |
| UniProt Protein Function: | SRCAP: Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Acetyltransferase; EC 3.6.4.-; Helicase; EC 3.6.1.-; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: nucleoplasm; Golgi apparatus; protein complex; perinuclear region of cytoplasm; nucleus Molecular Function:protein binding; histone acetyltransferase activity; DNA binding; transcription coactivator activity; helicase activity; ATP binding Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral reproduction; histone acetylation Disease: Floating-harbor Syndrome |
| NCBI Summary: | This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q6ZRS2 |
| NCBI GenInfo Identifier: | 146219843 |
| NCBI Gene ID: | 10847 |
| NCBI Accession: | NP_006653.2 |
| UniProt Secondary Accession: | Q6ZRS2,O15026, Q7Z744, Q9Y5L9, B0JZA6, |
| UniProt Related Accession: | Q6ZRS2 |
| Molecular Weight: | 327,838 Da |
| NCBI Full Name: | helicase SRCAP |
| NCBI Synonym Full Names: | Snf2-related CREBBP activator protein |
| NCBI Official Symbol: | SRCAP |
| NCBI Official Synonym Symbols: | EAF1; FLHS; SWR1; DOMO1 |
| NCBI Protein Information: | helicase SRCAP; domino homolog 2; Snf2-related CBP activator protein; Swi2/Snf2-related ATPase homolog, domino homolog 1 |
| UniProt Protein Name: | Helicase SRCAP |
| UniProt Synonym Protein Names: | Domino homolog 2; Snf2-related CBP activator |
| Protein Family: | Helicase |
| UniProt Gene Name: | SRCAP |
| UniProt Entry Name: | SRCAP_HUMAN |