Anti-SMG6 Antibody (CAB10141)

(No reviews yet) Write a Review
お見積り依頼
SKU:
CAB10141
Product type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€0.00
Frequently bought together:

Description

system_update_altデータシートsystem_update_alt安全性データシート
抗体名:Anti-SMG6 Antibody
抗体コード:CAB10141
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Rat
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1419 of human SMG6 (NP_060045.4).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Rat
ポジティブサンプル:HeLa, Jurkat, SW620, Rat liver
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1160-1419 of human SMG6 (NP_060045.4).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:PDTM GKEM GSQE GTRL EDEE EDVV IEDF EEDS EAEG SGGE DDIR ELRA KKLA LARK IAEQ QRRQ EKIQ AVLE DHSQ MRQM ELEI RPLF LVPD TNGF IDHL ASLA RLLE SRKY ILVV PLIV INEL DGLA KGQE TDHR AGGY ARVV QEKA RKSI EFLE QRFE SRDS CLRA LTSR GNEL ESIA FRSE DITG QLGN NDDL ILSC CLHY CKDK AKDF MPAS KEEP IRLL REVV LLTD DRNL RVKA LTRN VPVR DIPA FLTW AQVG
遺伝子ID:23293
Uniprot:Q86US8
セルラーロケーション:Chromosome, Cytoplasm, Nucleus, cytosol, nucleolus, telomere
計算された分子量:37kDa/57kDa/160kDa
観察された分子量:210kDa
同義語:SMG6, C17orf31, EST1A, SMG-6, hSMG5/7a
バックグラウンド:This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described.
UniProt Protein Function:Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)4GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).
NCBI Summary:This gene encodes a component of the telomerase ribonucleoprotein complex responsible for the replication and maintenance of chromosome ends. The encoded protein also plays a role in the nonsense-mediated mRNA decay (NMD) pathway, providing the endonuclease activity near the premature translation termination codon that is needed to initiate NMD. Alternatively spliced transcript variants encoding distinct protein isoforms have been described. [provided by RefSeq, Feb 2014]
UniProt Code:Q86US8
NCBI GenInfo Identifier:378744173
NCBI Gene ID:23293
NCBI Accession:NP_001243756.1
UniProt Secondary Accession:Q86US8,O94837, Q86VH6, Q9UF60, B7Z874,
UniProt Related Accession:Q86US8
Molecular Weight:57,455 Da
NCBI Full Name:telomerase-binding protein EST1A isoform 3
NCBI Synonym Full Names:SMG6, nonsense mediated mRNA decay factor
NCBI Official Symbol:SMG6  
NCBI Official Synonym Symbols:EST1A; SMG-6; C17orf31; hSMG5/7a  
NCBI Protein Information:telomerase-binding protein EST1A
UniProt Protein Name:Telomerase-binding protein EST1A
UniProt Synonym Protein Names:EST1-like protein A; Ever shorter telomeres 1A; Smg-6 homolog; Telomerase subunit EST1A; hSmg5/7a
Protein Family:Telomerase-binding protein
UniProt Gene Name:SMG6  
Anti-SMG6 Antibody (CAB10141)Western blot analysis of extracts of various cell lines, using SMG6 antibody (CAB10141) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
View AllClose

View AllClose