Anti-SLC26A4 Antibody (CAB16413)
- SKU:
- CAB16413
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
| 抗体名: | Anti-SLC26A4 Antibody |
| 抗体コード: | CAB16413 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SLC26A4 (NP_000432.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | mouse liver |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SLC26A4 (NP_000432.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VLSI IYTL VEIF QNIG DTNL ADFT AGLL TIVV CMAV KELN DRFR HKIP VPIP IEVI VTII ATAI SYGA NLEK NYNA GIVK SIPR GFLP PELP PVSL FSEM L |
| 遺伝子ID: | 5172 |
| Uniprot: | O43511 |
| セルラーロケーション: | Cell membrane, Membrane, Multi-pass membrane protein |
| 計算された分子量: | 39kDa/85kDa |
| 観察された分子量: | 86kDa |
| 同義語: | SLC26A4, DFNB4, EVA, PDS, TDH2B, pendrin |
| バックグラウンド: | Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. |
| UniProt Protein Function: | SLC26A4: Sodium-independent transporter of chloride and iodide. Defects in SLC26A4 are a cause of Pendred syndrome (PDS). PDS is an autosomal recessive disorder characterized by congenital sensorineural hearing loss combined with thyroid goiter. The disorder may account for up to 10% of the cases of hereditary deafness. The deafness is most often associated with a Mondini cochlear defect. Defects in SLC26A4 are the cause of deafness autosomal recessive type 4 (DFNB4); also known as vestibular aqueduct syndrome (EVA). DFNB4 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNB4 is associated with an enlarged vestibular aqueduct. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. |
| UniProt Protein Details: | Protein type:Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q31 Cellular Component: apical plasma membrane; brush border membrane; integral to membrane; integral to plasma membrane; plasma membrane Molecular Function:anion:anion antiporter activity; bicarbonate transmembrane transporter activity; chloride channel activity; chloride transmembrane transporter activity; iodide transmembrane transporter activity; oxalate transmembrane transporter activity; sulfate transmembrane transporter activity Biological Process: bicarbonate transport; inorganic anion transport; ion transport; regulation of intracellular pH; regulation of membrane potential; regulation of pH; regulation of protein localization; sensory perception of sound; sulfate transport Disease: Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct; Pendred Syndrome |
| NCBI Summary: | Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43511 |
| NCBI GenInfo Identifier: | 6174895 |
| NCBI Gene ID: | 5172 |
| NCBI Accession: | O43511.1 |
| UniProt Secondary Accession: | O43511,O43170, B7Z266, |
| UniProt Related Accession: | O43511 |
| Molecular Weight: | 39,267 Da |
| NCBI Full Name: | Pendrin |
| NCBI Synonym Full Names: | solute carrier family 26 member 4 |
| NCBI Official Symbol: | SLC26A4 |
| NCBI Official Synonym Symbols: | EVA; PDS; DFNB4; TDH2B |
| NCBI Protein Information: | pendrin |
| UniProt Protein Name: | Pendrin |
| UniProt Synonym Protein Names: | Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4 |
| Protein Family: | Pendrin |
| UniProt Gene Name: | SLC26A4 |
| UniProt Entry Name: | S26A4_HUMAN |
 | Western blot analysis of extracts of mouse liver, using SLC26A4 antibody (CAB16413) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3 minute. |