Anti-SIVA1 Antibody (CAB6326)
- SKU:
- CAB6326
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-SIVA1 Antibody |
| 抗体コード: | CAB6326 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SIVA1 (NP_068355.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | MCF7, SW620 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SIVA1 (NP_068355.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPKR SCPF ADVA PLQL KVRV SQRE LSRG VCAE RYSQ EVFD PSGV ASIA CSSC VRAV DGKA VCGQ CERA LCGQ CVRT CWGC GSVA CTLC GLVD CSDM YEKV LCTS CAMF ET |
| 遺伝子ID: | 10572 |
| Uniprot: | O15304 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 11kDa/18kDa |
| 観察された分子量: | 15kDa |
| 同義語: | SIVA1, CD27BP, SIVA, Siva-1, Siva-2 |
| バックグラウンド: | This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. |
| UniProt Protein Function: | Siva: a proapoptotic protein. Associates with CD27, a member of the tumor necrosis factor receptor family. Two alternatively spliced isoforms have been described. Isoform 1 but not isoform 2 may induce TNFRSF7/CD27 mediated apoptosis. Isoform 1 inhibits Bcl-xL anti-apoptotic activity. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; nucleus Molecular Function:viral receptor activity; protein binding; zinc ion binding; metal ion binding; CD27 receptor binding Biological Process: entry of virus into host cell; inhibition of NF-kappaB transcription factor; activated T cell apoptosis |
| NCBI Summary: | This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15304 |
| NCBI GenInfo Identifier: | 31077008 |
| NCBI Gene ID: | 10572 |
| NCBI Accession: | O15304.2 |
| UniProt Secondary Accession: | O15304,Q96P98, Q9UPD6, |
| UniProt Related Accession: | O15304 |
| Molecular Weight: | 175 |
| NCBI Full Name: | Apoptosis regulatory protein Siva |
| NCBI Synonym Full Names: | SIVA1, apoptosis-inducing factor |
| NCBI Official Symbol: | SIVA1 |
| NCBI Official Synonym Symbols: | SIVA; CD27BP; Siva-1; Siva-2 |
| NCBI Protein Information: | apoptosis regulatory protein Siva; CD27-binding (Siva) protein |
| UniProt Protein Name: | Apoptosis regulatory protein Siva |
| UniProt Synonym Protein Names: | CD27-binding protein; CD27BP |
| Protein Family: | Apoptosis regulatory protein |
| UniProt Gene Name: | SIVA1 |
| UniProt Entry Name: | SIVA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SIVA1 antibody (CAB6326) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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