Anti-SIRT4 Antibody (CAB15800)
- SKU:
- CAB15800
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-SIRT4 Antibody |
| 抗体コード: | CAB15800 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SIRT4 (NP_036372.1). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SIRT4 (NP_036372.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKMS FALT FRSA KGRW IANP SQPC SKAS IGLF VPAS PPLD PEKV KELQ RFIT LSKR LLVM TGAG ISTE SGIP DYRS EKVG LYAR TDRR PIQH GDFV RSAP IRQR YWAR NFVG WPQF SSHQ PNPA HWAL STWE KLGK LYWL VTQN VDAL HTKA GSRR LTEL HGCM DRVL CLDC GEQT PRGV LQER FQVL NPTW SAEA HGLA |
| 遺伝子ID: | 23409 |
| Uniprot: | Q9Y6E7 |
| セルラーロケーション: | Mitochondrion matrix |
| 計算された分子量: | 35kDa |
| 観察された分子量: |
| 同義語: | SIRT4, SIR2L4, sirtuin 4 |
| バックグラウンド: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. |
| UniProt Protein Function: | SIRT4: NAD-dependent protein ADP-ribosyl transferase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1. Inhibits GLUD1 enzyme activity. Down- regulates insulin secretion. Has no detectable protein deacetylase activity. Belongs to the sirtuin family. Class II subfamily. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Mitochondrial; Deacetylase; EC 2.4.2.-; EC 3.5.1.- Chromosomal Location of Human Ortholog: 12q Cellular Component: mitochondrial matrix; mitochondrion Molecular Function:biotinidase activity; NAD+ ADP-ribosyltransferase activity; protein binding Biological Process: chromatin silencing; glutamine metabolic process; negative regulation of fatty acid oxidation; negative regulation of insulin secretion; positive regulation of lipid biosynthetic process; protein amino acid ADP-ribosylation; response to DNA damage stimulus |
| NCBI Summary: | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y6E7 |
| NCBI GenInfo Identifier: | 38258657 |
| NCBI Gene ID: | 23409 |
| NCBI Accession: | Q9Y6E7.1 |
| UniProt Secondary Accession: | Q9Y6E7,O43346, Q32M33, |
| UniProt Related Accession: | Q9Y6E7 |
| Molecular Weight: | 35,188 Da |
| NCBI Full Name: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
| NCBI Synonym Full Names: | sirtuin 4 |
| NCBI Official Symbol: | SIRT4 |
| NCBI Official Synonym Symbols: | SIR2L4 |
| NCBI Protein Information: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
| UniProt Protein Name: | NAD-dependent protein lipoamidase sirtuin-4, mitochondrial |
| UniProt Synonym Protein Names: | NAD-dependent ADP-ribosyltransferase sirtuin-4 |
| Protein Family: | NAD-dependent protein deacylase |
| UniProt Gene Name: | SIRT4 |
| UniProt Entry Name: | SIR4_HUMAN |
 | Immunofluorescence analysis of U2OS cells using SIRT4 antibody (CAB15800) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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