Anti-SIGLEC7 Antibody (CAB4638)
- SKU:
- CAB4638
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SIGLEC7 Antibody |
| 抗体コード: | CAB4638 |
| 抗体サイズ: | 100µL |
| 申し込み: | WB IHC |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SIGLEC7 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:20 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: | A-549 |
| 免疫原: | Recombinant protein of human SIGLEC7 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 27036 |
| Uniprot: | Q9Y286 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 16kDa/41kDa/51kDa |
| 観察された分子量: | 70kDa |
| 同義語: | SIGLEC7, AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1 |
| バックグラウンド: |
| UniProt Protein Function: | SIGLEC7: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: integral to plasma membrane Molecular Function:receptor activity; carbohydrate binding Biological Process: cell adhesion |
| UniProt Code: | Q9Y286 |
| NCBI GenInfo Identifier: | 25009269 |
| NCBI Gene ID: | 27036 |
| NCBI Accession: | Q9Y286.1 |
| UniProt Related Accession: | Q9Y286 |
| Molecular Weight: | |
| NCBI Full Name: | Sialic acid-binding Ig-like lectin 7 |
| NCBI Synonym Full Names: | sialic acid binding Ig like lectin 7 |
| NCBI Official Symbol: | SIGLEC7 |
| NCBI Official Synonym Symbols: | p75; QA79; AIRM1; CD328; CDw328; D-siglec; SIGLEC-7; SIGLECP2; SIGLEC19P; p75/AIRM1 |
| NCBI Protein Information: | sialic acid-binding Ig-like lectin 7 |
| UniProt Protein Name: | Sialic acid-binding Ig-like lectin 7 |
| UniProt Synonym Protein Names: | Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD_antigen: CD328 |
| UniProt Gene Name: | SIGLEC7 |
| UniProt Entry Name: | SIGL7_HUMAN |
 | Western blot analysis of extracts of A-549 cells, using SIGLEC7 antibody (CAB4638). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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