Anti-SHPK Antibody (CAB8823)
- SKU:
- CAB8823
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SHPK Antibody |
| 抗体コード: | CAB8823 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human SHPK (NP_037408.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A375, Mouse kidney, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human SHPK (NP_037408.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAR PITL GIDL GTTS VKAA LLRA APDD PSGF AVLA SCAR AARA EAAV ESAV AGPQ GREQ DVSR ILQA LHEC LAAL PRPQ LRSV VGIG VSGQ MHGV VFWK TGQG CEWT EGGI TPVF EPRA VSHL VTWQ DGRC SSEF LASL PQPK SHLS VATG FGCA TIFW LLKY RPEF LKSY DAAG TIHD YVVA MLCG LPRP LMSD QNAA SWGY FNTQ SQSW NVET LRSS GFPV HLLP DIAE PGSV AGRT SHMW FEIP KGTQ VGVA LGDL QASV YSCM AQRT DAVL NIST SVQL AASM PSGF QPAQ TPDP TAPV AYFP YFNR TYLG VAAS |
| 遺伝子ID: | 23729 |
| Uniprot: | Q9UHJ6 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 51kDa |
| 観察された分子量: | 50kDa |
| 同義語: | SHPK, CARKL, SHK |
| バックグラウンド: | The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. |
| UniProt Protein Function: | SHPK: has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:EC 2.7.1.14; Kinase, other Chromosomal Location of Human Ortholog: 17p13 Cellular Component: cytoplasm Molecular Function:sedoheptulokinase activity; ATP binding Biological Process: regulation of macrophage activation; carbohydrate metabolic process; regulation of inflammatory response; pentose-phosphate shunt, non-oxidative branch; phosphorylation |
| NCBI Summary: | The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHJ6 |
| NCBI GenInfo Identifier: | 74315356 |
| NCBI Gene ID: | 23729 |
| NCBI Accession: | NP_037408.2 |
| UniProt Secondary Accession: | Q9UHJ6,Q8WUH3, B2R640, |
| UniProt Related Accession: | Q9UHJ6 |
| Molecular Weight: | 51,491 Da |
| NCBI Full Name: | sedoheptulokinase |
| NCBI Synonym Full Names: | sedoheptulokinase |
| NCBI Official Symbol: | SHPK |
| NCBI Official Synonym Symbols: | SHK; CARKL |
| NCBI Protein Information: | sedoheptulokinase |
| UniProt Protein Name: | Sedoheptulokinase |
| UniProt Synonym Protein Names: | Carbohydrate kinase-like protein |
| Protein Family: | Sedoheptulokinase |
| UniProt Gene Name: | SHPK |
| UniProt Entry Name: | SHPK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SHPK antibody (CAB8823) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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