Anti-SF3B3 Antibody (CAB9624)
- SKU:
- CAB9624
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-SF3B3 Antibody |
| 抗体コード: | CAB9624 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human SF3B3 |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Mouse testis, Rat lung |
| 免疫原: | A synthesized peptide derived from human SF3B3 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 23450 |
| Uniprot: | Q15393 |
| セルラーロケーション: | |
| 計算された分子量: | 136kDa |
| 観察された分子量: | 136KDa |
| 同義語: | RSE1, SAP130, SF3b130, STAF130 |
| バックグラウンド: | This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | SF3B3: Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Belongs to the RSE1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 16q22.1 Cellular Component: nucleolus; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex; spliceosome; U12-dependent spliceosome Molecular Function:protein binding; RNA binding Biological Process: mRNA processing; negative regulation of protein catabolic process; nuclear mRNA splicing, via spliceosome; protein complex assembly; RNA splicing; RNA splicing, via transesterification reactions |
| NCBI Summary: | This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15393 |
| NCBI GenInfo Identifier: | 116242787 |
| NCBI Gene ID: | 23450 |
| NCBI Accession: | Q15393.4 |
| UniProt Secondary Accession: | Q15393,Q6NTI8, Q96GC0, Q9BPY2, Q9UFX7, Q9UJ29, |
| UniProt Related Accession: | Q15393 |
| Molecular Weight: | 44,606 Da |
| NCBI Full Name: | Splicing factor 3B subunit 3 |
| NCBI Synonym Full Names: | splicing factor 3b subunit 3 |
| NCBI Official Symbol: | SF3B3 |
| NCBI Official Synonym Symbols: | RSE1; SAP130; SF3b130; STAF130 |
| NCBI Protein Information: | splicing factor 3B subunit 3 |
| UniProt Protein Name: | Splicing factor 3B subunit 3 |
| UniProt Synonym Protein Names: | Pre-mRNA-splicing factor SF3b 130 kDa subunit; SF3b130; STAF130; Spliceosome-associated protein 130; SAP 130 |
| Protein Family: | Splicing factor |
| UniProt Gene Name: | SF3B3 |
| UniProt Entry Name: | SF3B3_HUMAN |
 | Western blot - SF3B3 Rabbit mAb (CAB9624) |
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