Anti-SF2/ASF Antibody (CAB4091)
- SKU:
- CAB4091
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-SF2/ASF Antibody |
| 抗体コード: | CAB4091 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human SF2/ASF |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, MCF7, Mouse brain, Rat brain |
| 免疫原: | A synthesized peptide derived from human SF2/ASF |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 6426 |
| Uniprot: | Q07955 |
| セルラーロケーション: | |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 33KDa |
| 同義語: | ASF, SF2, SF2p33, SFRS1, SRp30a |
| バックグラウンド: | This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014] |
| UniProt Protein Function: | SF2: a serine-arginine-rich splicing regulatory protein. Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3' splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice-site-containing pre-mRNA. Extensively phosphorylated on serine residues in the serine-arginine rich region. Three splice variant isoforms have been described. ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA splicing; Spliceosome Chromosomal Location of Human Ortholog: 17q22 Cellular Component: nucleoplasm; cytoplasm; nuclear speck; nucleus Molecular Function:mRNA binding; protein binding; RS domain binding; RNA binding; nucleotide binding Biological Process: transcription from RNA polymerase II promoter; in utero embryonic development; RNA splicing; regulation of mRNA stability; regulation of translation; nuclear mRNA splicing, via spliceosome; nuclear mRNA 5'-splice site recognition; mRNA splice site selection; regulation of nuclear mRNA splicing, via spliceosome; mRNA export from nucleus; regulation of transcription, DNA-dependent; gene expression; mRNA 3'-end processing; mRNA processing; termination of RNA polymerase II transcription; cardiac muscle contraction |
| NCBI Summary: | This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13. [provided by RefSeq, Jun 2014] |
| UniProt Code: | Q07955 |
| NCBI GenInfo Identifier: | 730773 |
| NCBI Gene ID: | 6426 |
| NCBI Accession: | Q07955.2 |
| UniProt Secondary Accession: | Q07955,Q13809, B2R6Z7, D3DTZ3, |
| UniProt Related Accession: | Q07955 |
| Molecular Weight: | Observed MW: 30kDaCalculated MW: 22kDa/27kDa/31kDa |
| NCBI Full Name: | Serine/arginine-rich splicing factor 1 |
| NCBI Synonym Full Names: | serine/arginine-rich splicing factor 1 |
| NCBI Official Symbol: | SRSF1 |
| NCBI Official Synonym Symbols: | ASF; SF2; SFRS1; SF2p33; SRp30a |
| NCBI Protein Information: | serine/arginine-rich splicing factor 1; splicing factor 2; SR splicing factor 1; alternative-splicing factor 1; pre-mRNA-splicing factor SF2, P33 subunit; splicing factor, arginine/serine-rich, 30-KD, A |
| UniProt Protein Name: | Serine/arginine-rich splicing factor 1 |
| UniProt Synonym Protein Names: | Alternative-splicing factor 1; ASF-1; Splicing factor, arginine/serine-rich 1; pre-mRNA-splicing factor SF2, P33 subunit |
| UniProt Gene Name: | SRSF1 |
| UniProt Entry Name: | SRSF1_HUMAN |
 | Western blot - SF2/ASF Rabbit mAb (CAB4091) |
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