Anti-SETD6 Antibody (CAB7242)
- SKU:
- CAB7242
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SETD6 Antibody |
| 抗体コード: | CAB7242 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 301-473 of human SETD6 (NP_001153777.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | BT-474, Mouse liver, Mouse kidney, Rat brain, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 301-473 of human SETD6 (NP_001153777.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EPYP DNTD DTAD IQMV TVRE AALQ GTKT EAER HLVY ERWD FLCK LEMV GEEG AFVI GREE VLTE EELT TTLK VLCM PAEE FREL KDQD GGGD DKRE EGSL TITN IPKL KASW RQLL QNSV LLTL QTYA TDLK TDQG LLSN KEVY AKLS WREQ QALQ VRYG QKMI LHQL LELT S |
| 遺伝子ID: | 79918 |
| Uniprot: | Q8TBK2 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 50kDa/53kDa |
| 観察された分子量: | 53kDa |
| 同義語: | SETD6 |
| バックグラウンド: | This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | SETD6: Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. Belongs to the SETD6 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Methyltransferase; Methyltransferase, protein lysine; EC 2.1.1.- Chromosomal Location of Human Ortholog: 16q21 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:NF-kappaB binding; protein binding; protein-lysine N-methyltransferase activity Biological Process: inhibition of NF-kappaB transcription factor; peptidyl-lysine mono-methylation; regulation of inflammatory response |
| UniProt Code: | Q8TBK2 |
| NCBI GenInfo Identifier: | 308153495 |
| NCBI Gene ID: | 79918 |
| NCBI Accession: | Q8TBK2.2 |
| UniProt Secondary Accession: | Q8TBK2,Q9H787, A8K380, B5ME38, |
| UniProt Related Accession: | Q8TBK2 |
| Molecular Weight: | 473 |
| NCBI Full Name: | N-lysine methyltransferase SETD6 |
| NCBI Synonym Full Names: | SET domain containing 6 |
| NCBI Official Symbol: | SETD6 |
| NCBI Protein Information: | N-lysine methyltransferase SETD6; SET domain-containing protein 6 |
| UniProt Protein Name: | N-lysine methyltransferase SETD6 |
| UniProt Synonym Protein Names: | SET domain-containing protein 6 |
| Protein Family: | N-lysine methyltransferase |
| UniProt Gene Name: | SETD6 |
| UniProt Entry Name: | SETD6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SETD6 antibody (CAB7242) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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