Anti-SELL Antibody (CAB1622)
- SKU:
- CAB1622
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SELL Antibody |
抗体コード: | CAB1622 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SELL (NP_000646.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Jurkat, Raji, Mouse spleen, Mouse thymus, Rat thymus |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SELL (NP_000646.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MGCR RTRE GPSK AMIF PWKC QSTQ RDLW NIFK LWGW TMLC CDFL AHHG TDCW TYHY SEKP MNWQ RARR FCRD NYTD LVAI QNKA EIEY LEKT LPFS RSYY |
遺伝子ID: | 6402 |
Uniprot: | P14151 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 42kDa/43kDa |
観察された分子量: | 74kDa |
同義語: | SELL, CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1 |
バックグラウンド: | This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | SELL: Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. Belongs to the selectin/LECAM family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23-q25 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:heparin binding; protein binding; protease binding; cell adhesion molecule binding; glycosphingolipid binding; carbohydrate binding Biological Process: regulation of immune response; blood coagulation; cell adhesion; leukocyte migration; response to ATP Disease: Iga Nephropathy, Susceptibility To, 1 |
NCBI Summary: | This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] |
UniProt Code: | P14151 |
NCBI GenInfo Identifier: | 126178 |
NCBI Gene ID: | 6402 |
NCBI Accession: | P14151.2 |
UniProt Secondary Accession: | P14151,P15023, Q9UJ43, B2R6Q8, |
UniProt Related Accession: | P14151 |
Molecular Weight: | 43,618 Da |
NCBI Full Name: | L-selectin |
NCBI Synonym Full Names: | selectin L |
NCBI Official Symbol: | SELL |
NCBI Official Synonym Symbols: | TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1 |
NCBI Protein Information: | L-selectin; gp90-MEL; pln homing receptor; lymph node homing receptor; lymphocyte adhesion molecule 1; leukocyte surface antigen Leu-8; CD62 antigen-like family member L; leukocyte-endothelial cell adhesion molecule 1 |
UniProt Protein Name: | L-selectin |
UniProt Synonym Protein Names: | CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD_antigen: CD62L |
Protein Family: | L-selectin |
UniProt Gene Name: | SELL |
UniProt Entry Name: | LYAM1_HUMAN |
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