| UniProt Protein Function: | syndecan-4: a heparan sulfate proteoglycan type I membrane protein that belongs to the syndecan proteoglycan family. Expressed as a homodimer. Promotes cell spreading in a beta(1) integrin-dependent fashion through PKC-alpha and Rho. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 20q12 Cellular Component: lysosomal lumen; focal adhesion; costamere; cell surface; Golgi lumen; integral to plasma membrane; plasma membrane; lipid raft Molecular Function:protein binding; protein kinase C binding; fibronectin binding Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan biosynthetic process; phototransduction, visible light; extracellular matrix organization and biogenesis; glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; positive regulation of focal adhesion formation; ureteric bud development; positive regulation of protein kinase activity; positive regulation of stress fiber formation; carbohydrate metabolic process; pathogenesis; retinoid metabolic process |
| NCBI Summary: | The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31431 |
| NCBI GenInfo Identifier: | 38201675 |
| NCBI Gene ID: | 6385 |
| NCBI Accession: | NP_002990.2 |
| UniProt Secondary Accession: | P31431,O00773, Q16833, Q53FN9, Q6FGN3, |
| UniProt Related Accession: | P31431 |
| Molecular Weight: | 21,642 Da |
| NCBI Full Name: | syndecan-4 |
| NCBI Synonym Full Names: | syndecan 4 |
| NCBI Official Symbol: | SDC4 |
| NCBI Official Synonym Symbols: | SYND4 |
| NCBI Protein Information: | syndecan-4; amphiglycan; ryudocan amphiglycan; ryudocan core protein; syndecan proteoglycan 4; syndecan 4 (amphiglycan, ryudocan) |
| UniProt Protein Name: | Syndecan-4 |
| UniProt Synonym Protein Names: | Amphiglycan; Ryudocan core protein |
| Protein Family: | Syndecan |
| UniProt Gene Name: | SDC4 |
| UniProt Entry Name: | SDC4_HUMAN |
