Anti-RRAGD Antibody (CAB9979)
- SKU:
- CAB9979
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-RRAGD Antibody |
抗体コード: | CAB9979 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-400 of human RRAGD (NP_067067.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:1000 - 1:4000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | SH-SY5Y, NCI-H460, SW480, HL-60, 22Rv1, Mouse heart, Mouse skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-400 of human RRAGD (NP_067067.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | VDGL SDDH KIET QRDI HQRA NDDL ADAG LEKI HLSF YLTS IYDH SIFE AFSK VVQK LIPQ LPTL ENLL NIFI SNSG IEKA FLFD VVSK IYIA TDST PVDM QTYE LCCD MIDV VIDI SCIY GLKE DGAG TPYD KEST AIIK LNNT TVLY LKEV TKFL ALVC FVRE ESFE RKGL IDYN FHCF RKAI HEVF EVRM KVVK SRKV QNRL QKKK RATP NGTP RVLL |
遺伝子ID: | 58528 |
Uniprot: | Q9NQL2 |
セルラーロケーション: | Cytoplasm, Lysosome, Nucleus |
計算された分子量: | 28kDa/45kDa |
観察された分子量: | 46kDa |
同義語: | RRAGD, RAGD, bA11D8.2.1 |
バックグラウンド: |
UniProt Protein Function: | RRAGD: Has guanine nucleotide-binding activity but lacks intrinsic GTPase activity. Probably required for the amino acid- induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB. Belongs to the GTR/RAG GTP-binding protein family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:G protein regulator, misc. Chromosomal Location of Human Ortholog: 6q15 Cellular Component: cytoplasm; cytosol; lysosome; nucleus Molecular Function:GTPase activity; protein binding; protein heterodimerization activity Biological Process: cell cycle arrest; cellular response to starvation; macroautophagy; positive regulation of TOR signaling pathway; regulation of autophagy |
NCBI Summary: | RRAGD is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.[supplied by OMIM, Apr 2004] |
UniProt Code: | Q9NQL2 |
NCBI GenInfo Identifier: | 74752904 |
NCBI Gene ID: | 58528 |
NCBI Accession: | Q9NQL2.1 |
UniProt Secondary Accession: | Q9NQL2,Q7L8F9, Q9NPG0, A8K184, |
UniProt Related Accession: | Q9NQL2 |
Molecular Weight: | 28,611 Da |
NCBI Full Name: | Ras-related GTP-binding protein D |
NCBI Synonym Full Names: | Ras related GTP binding D |
NCBI Official Symbol: | RRAGD |
NCBI Official Synonym Symbols: | RAGD; bA11D8.2.1 |
NCBI Protein Information: | ras-related GTP-binding protein D |
UniProt Protein Name: | Ras-related GTP-binding protein D |
UniProt Gene Name: | RRAGD |
UniProt Entry Name: | RRAGD_HUMAN |
View AllClose