Anti-RPRD1B Antibody (CAB10102)
- SKU:
- CAB10102
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-RPRD1B Antibody |
| 抗体コード: | CAB10102 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human rprd1b |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, SKOV3, NCI-H460, Mouse liver, Mouse lung, Mouse stomach, Mouse spleen, Rat liver |
| 免疫原: | Recombinant protein of human rprd1b |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 58490 |
| Uniprot: | Q9NQG5 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 36kDa |
| 観察された分子量: | 37kDa |
| 同義語: | RPRD1B, C20orf77, CREPT, NET60, dJ1057B20.2, K-H, Kub5-Hera, rprd1b |
| バックグラウンド: |
| UniProt Protein Function: | RPRD1B: Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. Belongs to the UPF0400 (RTT103) family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 20q11.23 Cellular Component: centrosome; cytosol; DNA-directed RNA polymerase II, holoenzyme; nucleoplasm; nucleus Molecular Function:protein binding Biological Process: positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter |
| UniProt Code: | Q9NQG5 |
| NCBI GenInfo Identifier: | 23813907 |
| NCBI Gene ID: | 58490 |
| NCBI Accession: | Q9NQG5.1 |
| UniProt Secondary Accession: | Q9NQG5,Q1WDE7, Q6PKF4, |
| UniProt Related Accession: | Q9NQG5 |
| Molecular Weight: | 37kDa |
| NCBI Full Name: | Regulation of nuclear pre-mRNA domain-containing protein 1B |
| NCBI Synonym Full Names: | regulation of nuclear pre-mRNA domain containing 1B |
| NCBI Official Symbol: | RPRD1B |
| NCBI Official Synonym Symbols: | CREPT; NET60; C20orf77; dJ1057B20.2 |
| NCBI Protein Information: | regulation of nuclear pre-mRNA domain-containing protein 1B |
| UniProt Protein Name: | Regulation of nuclear pre-mRNA domain-containing protein 1B |
| UniProt Synonym Protein Names: | Cell cycle-related and expression-elevated protein in tumor |
| Protein Family: | Regulation of nuclear pre-mRNA domain-containing protein |
| UniProt Gene Name: | RPRD1B |
 | Western blot analysis of extracts of various cell lines, using rprd1b antibody (CAB10102) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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