Anti-RORC Antibody (CAB10240)
- SKU:
- CAB10240
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RORC Antibody |
| 抗体コード: | CAB10240 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-320 of human RORC (NP_005051.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, HT-29, 293T, HepG2, BT-474, Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-320 of human RORC (NP_005051.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KQLQ QRQQ QQQE PVVK TPPA GAQG ADTL TYTL GLPD GQLP LGSS PDLP EASA CPPG LLKA SGSG PSYS NNLA KAGL NGAS CHLE YSPE RGKA EGRE SFYS TGSQ LTPD RCGL RFEE HRHP GLGE LGQG PDSY GSPS FRST PEAP YASL TEIE HLVQ SVCK SYRE TCQL RLED LLRQ RSNI FSRE EVTG YQRK SMWE MWER C |
| 遺伝子ID: | 6097 |
| Uniprot: | P51449 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 55kDa/58kDa |
| 観察された分子量: | 54kDa |
| 同義語: | RORC, IMD42, NR1F3, RORG, RZR-GAMMA, RZRG, TOR |
| バックグラウンド: | The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | RORC: Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; Nuclear receptor; DNA-binding Chromosomal Location of Human Ortholog: 1q21 Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus Molecular Function:oxysterol binding; protein binding; transcription factor activity Biological Process: circadian regulation of gene expression; positive regulation of circadian rhythm; positive regulation of transcription, DNA-dependent; regulation of fat cell differentiation; regulation of steroid metabolic process; transcription initiation from RNA polymerase II promoter; xenobiotic metabolic process Disease: Immunodeficiency 42 |
| NCBI Summary: | The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51449 |
| NCBI GenInfo Identifier: | 49066040 |
| NCBI Gene ID: | 6097 |
| NCBI Accession: | P51449.2 |
| UniProt Secondary Accession: | P51449,Q5SZR9, Q8N5V7, Q8NCY8, |
| UniProt Related Accession: | P51449 |
| Molecular Weight: | 55,813 Da |
| NCBI Full Name: | Nuclear receptor ROR-gamma |
| NCBI Synonym Full Names: | RAR related orphan receptor C |
| NCBI Official Symbol: | RORC |
| NCBI Official Synonym Symbols: | TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA |
| NCBI Protein Information: | nuclear receptor ROR-gamma |
| UniProt Protein Name: | Nuclear receptor ROR-gamma |
| UniProt Synonym Protein Names: | Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-related orphan receptor C; Retinoid-related orphan receptor-gamma |
| Protein Family: | Nuclear receptor |
| UniProt Gene Name: | RORC |
| UniProt Entry Name: | RORG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RORC antibody (CAB10240) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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