Anti-RLN2 Antibody (CAB6969)
- SKU:
- CAB6969
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RLN2 Antibody |
| 抗体コード: | CAB6969 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-185 of human RLN2 (NP_604390.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | 22Rv1 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-185 of human RLN2 (NP_604390.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DSWM EEVI KLCG RELV RAQI AICG MSTW SKRS LSQE DAPQ TPRP VAEI VPSF INKD TETI NMMS EFVA NLPQ ELKL TLSE MQPA LPQL QQHV PVLK DSSL LFEE FKKL IRNR QSEA ADSS PSEL KYLG LDTH SRKK RQLY SALA NKCC HVGC TKRS LARF C |
| 遺伝子ID: | 6019 |
| Uniprot: | P04090 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 12kDa/21kDa |
| 観察された分子量: | 21kDa |
| 同義語: | RLN2, H2, H2-RLX, RLXH2, bA12D24.1.1, bA12D24.1.2, relaxin 2 |
| バックグラウンド: | This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. |
| UniProt Protein Function: | RLN2: Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 9p24.1 Cellular Component: extracellular region Molecular Function:hormone activity Biological Process: female pregnancy |
| NCBI Summary: | Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In humans there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3, where RLN1 and RLN2 share high sequence homology. The active form of the protein encoded by this gene consists of an A chain and a B chain linked by disulfide bonds. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2013] |
| UniProt Code: | P04090 |
| NCBI GenInfo Identifier: | 132281 |
| NCBI Gene ID: | 6019 |
| NCBI Accession: | P04090.1 |
| UniProt Secondary Accession: | P04090,Q99936, Q9UCX3, Q9UQJ2, A0AVM0, |
| UniProt Related Accession: | P04090 |
| Molecular Weight: | 185 |
| NCBI Full Name: | Prorelaxin H2 |
| NCBI Synonym Full Names: | relaxin 2 |
| NCBI Official Symbol: | RLN2 |
| NCBI Official Synonym Symbols: | H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2 |
| NCBI Protein Information: | prorelaxin H2; H2-preprorelaxin; relaxin, ovarian, of pregnancy |
| UniProt Protein Name: | Prorelaxin H2 |
| Protein Family: | Prorelaxin |
| UniProt Gene Name: | RLN2 |
| UniProt Entry Name: | REL2_HUMAN |
 | Western blot analysis of extracts of 22Rv1 cells, using RLN2 antibody (CAB6969) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using RLN2 antibody (CAB6969) at dilution of 1:200 (40x lens). |
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