Anti-RGS6 Antibody (CAB18407)
- SKU:
- CAB18407
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-RGS6 Antibody |
| 抗体コード: | CAB18407 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human RGS6. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human RGS6. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 9628 |
| Uniprot: | P49758 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | GAP, HA117, S914, RGS6 |
| バックグラウンド: |
| UniProt Protein Function: | RGS6: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. 11 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: Golgi apparatus; cytoplasm; plasma membrane; heterotrimeric G-protein complex Molecular Function:protein domain specific binding; protein binding; signal transducer activity; GTPase activator activity Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of neuron differentiation; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] |
| UniProt Code: | P49758 |
| NCBI GenInfo Identifier: | 325053674 |
| NCBI Gene ID: | 9628 |
| NCBI Accession: | NP_001191345.1 |
| UniProt Secondary Accession: | P49758,O75576, O75577, Q7Z4K3, Q7Z4K4, Q7Z4K5, Q7Z4K6 Q8TE13, Q8TE14, Q8TE15, C9JE95, F8W7W5, |
| UniProt Related Accession: | P49758 |
| Molecular Weight: | 54,423 Da |
| NCBI Full Name: | regulator of G-protein signaling 6 isoform 1 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 6 |
| NCBI Official Symbol: | RGS6 |
| NCBI Official Synonym Symbols: | GAP |
| NCBI Protein Information: | regulator of G-protein signaling 6; S914; H_DJ1108A12.1; WUGSC:H_DJ0283M22.1; WUGSC:H_DJ1108A12.1; GTPase activating protein; regulator of G-protein signalling 6 |
| UniProt Protein Name: | Regulator of G-protein signaling 6 |
| UniProt Synonym Protein Names: | S914 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS6 |
| UniProt Entry Name: | RGS6_HUMAN |