Anti-Ret Antibody (CAB0018)
- SKU:
- CAB0018
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-Ret Antibody |
| 抗体コード: | CAB0018 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-300 of human Ret (NP_066124.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Neuro-2a |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-300 of human Ret (NP_066124.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LYFS RDAY WEKL YVDQ AAGT PLLY VHAL RDAP EEVP SFRL GQHL YGTY RTRL HENN WICI QEDT GLLY LNRS LDHS SWEK LSVR NRGF PLLT VYLK VFLS PTSL REGE CQWP GCAR VYFS FFNT SFPA CSSL KPRE LCFP ETRP SFRI RENR PPGT FHQF RLLP VQFL CPNI SVAY RLLE GEGL PFRC APDS LEVS TRWA LDRE QREK YELV AVCT VHAG AREE VVMV PFPV TVYD EDDS APTF PAGV DTAS AVVE FKRK EDTV VATL RVFD |
| 遺伝子ID: | 5979 |
| Uniprot: | P07949 |
| セルラーロケーション: | Cell membrane, Endosome membrane, Single-pass type I membrane protein |
| 計算された分子量: | 119kDa/124kDa |
| 観察された分子量: | 180kDa |
 | Western blot - Ret Rabbit pAb (CAB0018) |
| 同義語: | RET, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, RET51 |
| バックグラウンド: | This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. |
| UniProt Protein Function: | Ret: a proto-oncogenic receptor tyrosine kinase. Receptor for glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Part of a multicompetent receptor complex with other membrane-bound ligand-binding GDNF family receptors (aGFRs). Required for development of the kidney and neural crest-derived cell types. Three alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Protein kinase, TK; EC 2.7.10.1; Oncoprotein; Kinase, protein; Protein kinase, tyrosine (receptor); Membrane protein, integral; TK group; Ret family Chromosomal Location of Human Ortholog: 10q11.2 Cellular Component: cytoplasm; endosome membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane; receptor complex Molecular Function:calcium ion binding; protein binding; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor activity Biological Process: MAPKKK cascade; membrane protein proteolysis; neuron adhesion; positive regulation of cell adhesion mediated by integrin; positive regulation of cell migration; positive regulation of transcription, DNA-dependent; posterior midgut development; protein amino acid phosphorylation; regulation of cell adhesion; response to pain; signal transduction Disease: Hirschsprung Disease, Susceptibility To, 1; Multiple Endocrine Neoplasia, Type Iia; Multiple Endocrine Neoplasia, Type Iib; Thyroid Carcinoma, Familial Medullary; Thyroid Carcinoma, Papillary |
| NCBI Summary: | This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P07949 |
| NCBI GenInfo Identifier: | 547807 |
| NCBI Gene ID: | 5979 |
| NCBI Accession: | P07949.3 |
| UniProt Secondary Accession: | P07949,Q15250, Q9BTB0, Q9H4A2, A8K6Z2, |
| UniProt Related Accession: | P07949 |
| Molecular Weight: | 119,847 Da |
| NCBI Full Name: | Proto-oncogene tyrosine-protein kinase receptor Ret |
| NCBI Synonym Full Names: | ret proto-oncogene |
| NCBI Official Symbol: | RET |
| NCBI Official Synonym Symbols: | PTC; MTC1; HSCR1; MEN2A; MEN2B; RET51; CDHF12; CDHR16; RET-ELE1 |
| NCBI Protein Information: | proto-oncogene tyrosine-protein kinase receptor Ret |
| UniProt Protein Name: | Proto-oncogene tyrosine-protein kinase receptor Ret |
| UniProt Synonym Protein Names: | Cadherin family member 12; Proto-oncogene c-Ret |
| Protein Family: | Retbindin |
| UniProt Gene Name: | RET |
| UniProt Entry Name: | RET_HUMAN |