Anti-RAMP3 Antibody (CAB6715)
- SKU:
- CAB6715
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-RAMP3 Antibody |
| 抗体コード: | CAB6715 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RAMP3 (NP_005847.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, SW620, Mouse brain, Mouse skin, Mouse kidney, Mouse heart, Mouse eye, Rat brain, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RAMP3 (NP_005847.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | METG ALRR PQLL PLLL LLCG GCPR AGGC NETG MLER LPLC GKAF ADMM GKVD VWKW CNLS EFIV YYES FTNC TEME ANVV GCYW PNPL AQGF ITGI HRQF FSNC TVDR VHLE DPPD EV |
| 遺伝子ID: | 10268 |
| Uniprot: | O60896 |
| セルラーロケーション: | Cell membrane, Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 16kDa |
| 観察された分子量: | 40kDa |
| 同義語: | RAMP3 |
| バックグラウンド: | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. |
| UniProt Protein Function: | RAMP3: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 7p13-p12 Cellular Component: cell surface; integral to plasma membrane; lysosome; plasma membrane; intracellular; receptor complex Molecular Function:protein binding; coreceptor activity; receptor activity; protein transporter activity Biological Process: intracellular protein transport; protein transport; receptor internalization; calcium ion transport; negative regulation of transcription, DNA-dependent; positive regulation of receptor recycling; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O60896 |
| NCBI GenInfo Identifier: | 11134424 |
| NCBI Gene ID: | 10268 |
| NCBI Accession: | O60896.1 |
| UniProt Secondary Accession: | O60896,Q7Z2Y1, |
| UniProt Related Accession: | O60896 |
| Molecular Weight: | 148 |
| NCBI Full Name: | Receptor activity-modifying protein 3 |
| NCBI Synonym Full Names: | receptor (G protein-coupled) activity modifying protein 3 |
| NCBI Official Symbol: | RAMP3 |
| NCBI Protein Information: | receptor activity-modifying protein 3; CRLR activity-modifying protein 3; receptor activity modifying protein 3; receptor-activity-modifying protein 3; receptor (calcitonin) activity modifying protein 3; calcitonin receptor-like receptor activity modifyin |
| UniProt Protein Name: | Receptor activity-modifying protein 3 |
| UniProt Synonym Protein Names: | Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3 |
| Protein Family: | Receptor activity-modifying protein |
| UniProt Gene Name: | RAMP3 |
| UniProt Entry Name: | RAMP3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RAMP3 antibody (CAB6715) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of MCF7 cells using RAMP3 antibody (CAB6715). Blue: DAPI for nuclear staining. |
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