Anti-PXK Antibody (CAB15458)
- SKU:
- CAB15458
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-PXK Antibody |
| 抗体コード: | CAB15458 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PXK (NP_060241.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, U-251MG, Jurkat, Mouse spleen, Mouse lung, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PXK (NP_060241.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAFM EKPP AGKV LLDD TVPL TAAI EASQ SLQS HTEY IIRV QRGI SVEN SWQI VRRY SDFD LLNN SLQI AGLS LPLP PKKL IGNM DREF IAER QKGL QNYL NVIT TNHI LSNC ELVK KFLD PNNY SANY TEIA LQQV SMFF RSEP KWEV VEPL KDIG WRIR KKYF LMKI KNQP KERL VLSW ADLG PDKY LSDK DFQC LIKL |
| 遺伝子ID: | 54899 |
| Uniprot: | Q7Z7A4 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Peripheral membrane protein |
| 計算された分子量: | 38kDa/49kDa/55kDa/58kDa/60kDa/62kDa/64kDa |
| 観察された分子量: | 80kDa |
| 同義語: | PXK, MONAKA, SLOB, MONaKA |
| バックグラウンド: | This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Slob: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Belongs to the protein kinase superfamily. 7 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; Slob family Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: cytoplasm; plasma membrane; microtubule organizing center; nucleus Molecular Function:protein C-terminus binding; nucleotide binding; actin binding; ATP binding; phosphoinositide binding; protein kinase activity Biological Process: regulation of synaptic transmission; inflammatory response; protein amino acid phosphorylation; negative regulation of ion transport; negative regulation of ATPase activity |
| NCBI Summary: | PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 [PubMed 16135750]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q7Z7A4 |
| NCBI GenInfo Identifier: | 31543452 |
| NCBI Gene ID: | 54899 |
| NCBI Accession: | NP_060241.2 |
| UniProt Secondary Accession: | Q7Z7A4,Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3 Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8, |
| UniProt Related Accession: | Q7Z7A4 |
| Molecular Weight: | 64,950 Da |
| NCBI Full Name: | PX domain-containing protein kinase-like protein |
| NCBI Synonym Full Names: | PX domain containing serine/threonine kinase |
| NCBI Official Symbol: | PXK |
| NCBI Official Synonym Symbols: | MONaKA |
| NCBI Protein Information: | PX domain-containing protein kinase-like protein; PX ser/thr kinase v2; PX serine/threonine kinase; modulator of Na,K-ATPase long form |
| UniProt Protein Name: | PX domain-containing protein kinase-like protein |
| UniProt Synonym Protein Names: | Modulator of Na,K-ATPase |
| Protein Family: | PX domain-containing protein kinase-like protein |
| UniProt Gene Name: | PXK |
| UniProt Entry Name: | PXK_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PXK antibody (CAB15458) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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