Anti-PTPRA Antibody (CAB1976)
- SKU:
- CAB1976
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PTPRA Antibody |
| 抗体コード: | CAB1976 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-142 of human PTPRA (NP_543031.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | SW620, 22Rv1, BT-474, Mouse brain, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-142 of human PTPRA (NP_543031.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NNAT TVAP SVGI TRLI NSST AEPV KEEA KTSN PTSS LTSL SVAP TFSP NITL GPTY LTTV NSSD SDNG TTRT ASTN SIGI TISP NGTW LPDN QFTD ARTE PWEG NSST AATT PETF PPSD ETP |
| 遺伝子ID: | 5786 |
| Uniprot: | P18433 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 89kDa/90kDa |
| 観察された分子量: | 120kDa |
| 同義語: | PTPRA, HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA |
| バックグラウンド: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. |
| UniProt Protein Function: | PTPRA: a receptor protein tyrosine phosphatase (PTP). Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. Dephosphorylates and activates Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Four alternatively spliced isoforms have been reported. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; EC 3.1.3.48 Chromosomal Location of Human Ortholog: 20p13 Cellular Component: integral to plasma membrane; plasma membrane; receptor complex Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity Biological Process: axon guidance; insulin receptor signaling pathway; protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P18433 |
| NCBI GenInfo Identifier: | 126467 |
| NCBI Gene ID: | 5786 |
| NCBI Accession: | P18433.2 |
| UniProt Secondary Accession: | P18433,Q14513, Q7Z2I2, Q96TD9, A8K2G8, D3DVX5, |
| UniProt Related Accession: | P18433 |
| Molecular Weight: | 802 |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase alpha |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, A |
| NCBI Official Symbol: | PTPRA |
| NCBI Official Synonym Symbols: | LRP; HLPR; PTPA; HEPTP; HPTPA; RPTPA; PTPRL2; HPTPalpha; R-PTP-alpha |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase alpha; PTPase-alpha; PTPLCA-related phosphatase; tyrosine phosphatase alpha; protein-tyrosine phosphatase alpha; protein tyrosine phosphatase, receptor type, alpha polypeptide; Leukocyte common antigen-related peptide (protein tyrosine phosphate) |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase alpha |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRA |
| UniProt Entry Name: | PTPRA_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PTPRA antibody (CAB1976) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human colon using PTPRA Antibody (CAB1976) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human kidney using PTPRA Antibody (CAB1976) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using PTPRA Antibody (CAB1976) at dilution of 1:100 (40x lens). |
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