Anti-PSTPIP1 Antibody (CAB7760)
- SKU:
- CAB7760
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PSTPIP1 Antibody |
| 抗体コード: | CAB7760 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | THP-1, mouse spleen, mouse thymus, mouse brain, rat brain, Mouse spleen, Mouse thymus, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_003969.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AFER ISAN GHQK QVEK SQNK ARQC KDSA TEAE RVYR QSIA QLEK VRAE WEQE HRTT CEAF QLQE FDRL TILR NALW VHSN QLSM QCVK DDEL YEEV RLTL EGCS IDAD IDSF IQAK STGT EPPA PVPY QNYY DREV TPLT SSPG IQPS CGMI KRFS GLLH GSPK TTSL AASA ASTE TLTP TPER NEGV YTAI AVQE IQGN PASP AQEY RALY DYTA QNPD ELDL SAGD ILEV ILEG EDGW WTVE RNGQ RGFV PGSY LEKL |
| 遺伝子ID: | 9051 |
| Uniprot: | O43586 |
| セルラーロケーション: | Cell projection, Cleavage furrow, Cytoplasm, cytoskeleton, lamellipodium, perinuclear region, uropodium |
| 計算された分子量: | 45kDa/47kDa |
| 観察された分子量: | 48kDa |
| 同義語: | PSTPIP1, CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP |
| バックグラウンド: | This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. |
| UniProt Protein Function: | PSTPIP1: an SH3-domain containing protein that may play a role in vesicle formation and transport. Interacts with PTP-PEST to inhibit WASp-driven actin polymerization and synapse formation. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Adaptor/scaffold Chromosomal Location of Human Ortholog: 15q24.3 Cellular Component: membrane; lamellipodium; perinuclear region of cytoplasm; contractile ring; stress fiber; uropod; cytosol; cleavage furrow Molecular Function:protein binding; actin binding; protein phosphatase binding Biological Process: innate immune response; endocytosis; inflammatory response; signal transduction; cell adhesion Disease: Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne |
| NCBI Summary: | The protein encoded by this gene binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, negatively affecting CD2-triggered T cell activation. The encoded protein appears to be a scaffold protein and a regulator of the actin cytoskeleton. It has also been shown to bind ABL1, PTPN18, WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPA syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43586 |
| NCBI GenInfo Identifier: | 74739557 |
| NCBI Gene ID: | 9051 |
| NCBI Accession: | O43586.1 |
| UniProt Secondary Accession: | O43586,O43585, O95657, B5BU74, B5BUK4, |
| UniProt Related Accession: | O43586 |
| Molecular Weight: | 416 |
| NCBI Full Name: | Proline-serine-threonine phosphatase-interacting protein 1 |
| NCBI Synonym Full Names: | proline-serine-threonine phosphatase interacting protein 1 |
| NCBI Official Symbol: | PSTPIP1 |
| NCBI Official Synonym Symbols: | H-PIP; PAPAS; CD2BP1; PSTPIP; CD2BP1L; CD2BP1S |
| NCBI Protein Information: | proline-serine-threonine phosphatase-interacting protein 1; CD2-binding protein 1; CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; PEST phosphatase-interacting protein 1 |
| UniProt Protein Name: | Proline-serine-threonine phosphatase-interacting protein 1 |
| UniProt Synonym Protein Names: | CD2-binding protein 1; H-PIP |
| Protein Family: | Proline-serine-threonine phosphatase-interacting protein |
| UniProt Gene Name: | PSTPIP1 |
| UniProt Entry Name: | PPIP1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PSTPIP1 antibody (CAB7760) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 40s. |
 | Immunohistochemistry of paraffin-embedded human stomach using PSTPIP1 antibody (CAB7760) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using PSTPIP1 antibody (CAB7760) at dilution of 1:100 (40x lens). |
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