| UniProt Protein Function: | PSMD10: Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Proteasome complex; Protease Chromosomal Location of Human Ortholog: Xq22.3 Cellular Component: proteasome complex; nucleoplasm; intermediate filament cytoskeleton; proteasome regulatory particle; cytoplasm; nucleus; cytosol Molecular Function:protein binding; transcription factor binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of cyclin-dependent protein kinase activity; protein polyubiquitination; viral reproduction; apoptosis; negative regulation of transcription from RNA polymerase II promoter; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; antigen processing and presentation of peptide antigen via MHC class I; cytoplasmic sequestering of NF-kappaB; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; negative regulation of MAPKKK cascade; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of cell growth; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011] |
| UniProt Code: | O75832 |
| NCBI GenInfo Identifier: | 20532206 |
| NCBI Gene ID: | 5716 |
| NCBI Accession: | O75832.1 |
| UniProt Related Accession: | O75832 |
| Molecular Weight: | 16kDa; 24kDa |
| NCBI Full Name: | 26S proteasome non-ATPase regulatory subunit 10 |
| NCBI Synonym Full Names: | proteasome 26S subunit, non-ATPase 10 |
| NCBI Official Symbol: | PSMD10 |
| NCBI Official Synonym Symbols: | p28; p28(GANK); dJ889N15.2 |
| NCBI Protein Information: | 26S proteasome non-ATPase regulatory subunit 10 |
| UniProt Protein Name: | 26S proteasome non-ATPase regulatory subunit 10 |
| UniProt Synonym Protein Names: | 26S proteasome regulatory subunit p28; Gankyrin; p28(GANK) |
| Protein Family: | 26S proteasome non-ATPase regulatory |
| UniProt Gene Name: | PSMD10 |
| UniProt Entry Name: | PSD10_HUMAN |
