| UniProt Protein Function: | PRDM6: Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Methyltransferase; C2H2-type zinc finger protein; Methyltransferase, protein lysine; EC 2.1.1.43 Chromosomal Location of Human Ortholog: 5q23.2 |
| UniProt Code: | Q9NQX0 |
| NCBI GenInfo Identifier: | 223590133 |
| NCBI Gene ID: | 93166 |
| NCBI Accession: | Q9NQX0.2 |
| UniProt Secondary Accession: | Q9NQX0,Q9NQW9, B5MCJ4, |
| UniProt Related Accession: | Q9NQX0 |
| Molecular Weight: | 46,635 Da |
| NCBI Full Name: | Putative histone-lysine N-methyltransferase PRDM6 |
| NCBI Synonym Full Names: | PR/SET domain 6 |
| NCBI Official Symbol: | PRDM6 |
| NCBI Official Synonym Symbols: | PRISM |
| NCBI Protein Information: | putative histone-lysine N-methyltransferase PRDM6 |
| UniProt Protein Name: | Putative histone-lysine N-methyltransferase PRDM6 |
| UniProt Synonym Protein Names: | PR domain zinc finger protein 6; PR domain-containing protein 6 |
| Protein Family: | Putative histone-lysine N-methyltransferase |
| UniProt Gene Name: | PRDM6 |
| UniProt Entry Name: | PRDM6_HUMAN |
