Anti-PPIB Antibody (CAB7713)
- SKU:
- CAB7713
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-PPIB Antibody |
| 抗体コード: | CAB7713 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-216 of human PPIB (NP_000933.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, 22Rv1, HepG2, THP-1, Mouse liver, Mouse kidney, Mouse brain, Mouse lung, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 34-216 of human PPIB (NP_000933.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DEKK KGPK VTVK VYFD LRIG DEDV GRVI FGLF GKTV PKTV DNFV ALAT GEKG FGYK NSKF HRVI KDFM IQGG DFTR GDGT GGKS IYGE RFPD ENFK LKHY GPGW VSMA NAGK DTNG SQFF ITTV KTAW LDGK HVVF GKVL EGME VVRK VEST KTDS RDKP LKDV IIAD CGKI EVEK PFAI AKE |
| 遺伝子ID: | 5479 |
| Uniprot: | P23284 |
| セルラーロケーション: | Endoplasmic reticulum lumen, Melanosome |
| 計算された分子量: | 23kDa |
| 観察された分子量: | 24kDa |
| 同義語: | PPIB, CYP-S1, CYPB, HEL-S-39, OI9, SCYLP |
| バックグラウンド: | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. |
| UniProt Protein Function: | PPIB: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Defects in PPIB are the cause of osteogenesis imperfecta type 9 (OI9). OI9 is a connective tissue disorder characterized by bone fragility, low bone mass and bowing of limbs due to multiple fractures. Short limb dwarfism and blue sclerae are observed in some but not all patients. Belongs to the cyclophilin-type PPIase family. PPIase B subfamily. |
| UniProt Protein Details: | Protein type:Isomerase; Chaperone; EC 5.2.1.8; Secreted; Cyclophilin; Secreted, signal peptide; RNA-binding Chromosomal Location of Human Ortholog: 15q21-q22 Cellular Component: endoplasmic reticulum; endoplasmic reticulum lumen; focal adhesion; melanosome; membrane; nucleus; perinuclear region of cytoplasm; smooth endoplasmic reticulum Molecular Function:collagen binding; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; protein complex binding; unfolded protein binding Biological Process: extracellular matrix organization and biogenesis; positive regulation of multicellular organism growth; protein peptidyl-prolyl isomerization; protein stabilization Disease: Osteogenesis Imperfecta, Type Ix |
| NCBI Summary: | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P23284 |
| NCBI GenInfo Identifier: | 215273869 |
| NCBI Gene ID: | 5479 |
| NCBI Accession: | P23284.2 |
| UniProt Secondary Accession: | P23284,Q6IBH5, Q9BVK5, A8K534, |
| UniProt Related Accession: | P23284 |
| Molecular Weight: | 23,743 Da |
| NCBI Full Name: | Peptidyl-prolyl cis-trans isomerase B |
| NCBI Synonym Full Names: | peptidylprolyl isomerase B |
| NCBI Official Symbol: | PPIB |
| NCBI Official Synonym Symbols: | OI9; CYPB; SCYLP; CYP-S1; HEL-S-39 |
| NCBI Protein Information: | peptidyl-prolyl cis-trans isomerase B |
| UniProt Protein Name: | Peptidyl-prolyl cis-trans isomerase B |
| UniProt Synonym Protein Names: | CYP-S1; Cyclophilin B; Rotamase B; S-cyclophilin; SCYLP |
| Protein Family: | Probable peptidyl-prolyl cis-trans isomerase |
| UniProt Gene Name: | PPIB |
| UniProt Entry Name: | PPIB_HUMAN |
 | Western blot analysis of extracts of various cell lines, using PPIB antibody (CAB7713) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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